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UniProt Q9JK66

E3 ubiquitin-protein ligase parkin (Q9JK66)

E3 ubiquitin-protein ligase parkin (UniProt Q9JK66), EC 2.3.2.31: 10 experimental structures on GenesisL1, 2 ligands bound, 4 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt
Q9JK66
Protein
E3 ubiquitin-protein ligase parkin
EC
2.3.2.31
Experimental structures
10
Predicted models
0
Ligands
2
Pockets
4 · 1 record with a druggable one

Structures

10 records of Q9JK66 in the MolNFT archive: 10 experimental, 0 predicted.

EntryTitleMethodChainsLigandsPockets
2KNBSolution NMR structure of the parkin Ubl domain in complex with the endophilin-A1 SH3 domainsolution nmrA——
2KNBSolution NMR structure of the parkin ubl domain in complex with the endophilin-A1 SH3 domainsolution nmrA——
4K7DCrystal Structure of Parkin C-terminal RING domainsx-ray diffractionA, B, C——
4K7DCrystal structure of parkin C-terminal ring domainsx-ray diffractionA, B, C——
4K95Crystal Structure of Parkinx-ray diffractionA, B, C, D, E, F, G, H, I, J, K, L——
4K95Crystal structure of parkinx-ray diffractionA, B, C, D, E, F, G, H, I, J, K, L——
4ZYNCrystal Structure of Parkin E3 ubiquitin ligase (linker deletion; delta 86-130)x-ray diffractionA, B——
4ZYNCrystal structure of parkin E3 ubiquitin ligase (linker deletion; delta 86-130)x-ray diffractionA, B——
8W31Crystal structure of parkin (R0RB):2pUb with activator compoundx-ray diffractionAZN, A1AE94 (best 0.71)
Q9JK66AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase parkin (Q9JK66)———

Ligands

  • A1AE9 · (S)-1-(6-benzyl-3-(4-(1,2,3,4-tetrahydroquinoline-1-carbonyl)phenyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-5(4H)-yl)ethan-1-one · in 1 record
  • ZN · Zinc ion · in 1 record

Elsewhere

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