UniProt Q9I834
Basic phospholipase A2 homolog 2 (Q9I834)
Basic phospholipase A2 homolog 2 (UniProt Q9I834): 20 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9I834
- Protein
- Basic phospholipase A2 homolog 2
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 8 · 6 records with a druggable one
Structures
21 records of Q9I834 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1XXS | Structural insights for fatty acid binding in a Lys49 phospholipase A2: crystal structure of… | x-ray diffraction | A, B | — | — |
| 1XXS | Structural insights for fatty acid binding in a LYS49 phospholipase A2: crystal structure of… | x-ray diffraction | A, B | — | — |
| 4KF3 | Crystal Structure of Myotoxin II (MjTX-II), a myotoxic Lys49-phospholipase A2 from Bothrops moojeni. | x-ray diffraction | B, A | — | — |
| 4KF3 | Crystal structure of myotoxin II (mjtx-II), a myotoxic LYS49- phospholipase A2 from bothrops… | x-ray diffraction | B, A | — | — |
| 4YV5 | Crystal Structure of Myotoxin II from Bothrops moojeni complexed to Suramin | x-ray diffraction | B, A | — | — |
| 4YV5 | Crystal structure of myotoxin II from bothrops moojeni complexed to suramin | x-ray diffraction | B, A | — | — |
| 6B80 | Crystal structure of myotoxin II from Bothrops moojeni complexed to myristic acid | x-ray diffraction | A, B | MYR, SO4 | 1 (best 0.79) |
| 6B80 | Crystal structure of myotoxin II from bothrops moojeni complexed to myristic acid | x-ray diffraction | A, B | MYR, SO4 | — |
| 6B81 | Crystal structure of Myotoxin II from Bothrops moojeni complexed to Caprylic acid | x-ray diffraction | B, A | SO4, OCA | 1 (best 0.80) |
| 6B81 | Crystal structure of myotoxin II from bothrops moojeni complexed to caprylic acid | x-ray diffraction | B, A | SO4, OCA | — |
| 6B83 | Crystal structure of Myotoxin II from Bothrops moojeni complexed to Caproic acid | x-ray diffraction | B, A | 6NA, SO4 | 1 (best 0.81) |
| 6B83 | Crystal structure of myotoxin II from bothrops moojeni complexed to caproic acid | x-ray diffraction | B, A | 6NA, SO4 | — |
| 6B84 | Crystal structure of Myotoxin II from Bothrops moojeni | x-ray diffraction | B, A | SO4 | 2 (best 0.59) |
| 6B84 | Crystal structure of myotoxin II from bothrops moojeni | x-ray diffraction | B, A | SO4 | — |
| 6MQD | Myotoxin II from Bothrops moojeni complexed with Rosmarinic Acid | x-ray diffraction | A, B | ROA | — |
| 6MQD | Myotoxin II from bothrops moojeni complexed with rosmarinic acid | x-ray diffraction | A, B | ROA | — |
| 6MQF | Myotoxin II from Bothrops moojeni complexed with Acetylsalicylic acid | x-ray diffraction | A, B | AIN | — |
| 6MQF | Myotoxin II from bothrops moojeni complexed with acetylsalicylic acid | x-ray diffraction | A, B | AIN | — |
| 6PWH | Cystal structure of Myotoxin II from Bothrops moojeni co-crystallized with Varespladib (LY315920) | x-ray diffraction | A, B | VRD | 2 (best 0.66) |
| 6PWH | Cystal structure of myotoxin II from bothrops moojeni co-crystallized with varespladib (LY315920) | x-ray diffraction | A, B | VRD | — |
| Q9I834 | AlphaFold monomer V2.0 prediction for basic phospholipase A2 homolog myotoxin II (Q9I834) | predicted | A | — | 1 (best 0.56) |
Ligands
- SO4 · Sulfate ion · in 8 records
- 6NA · Hexanoic acid · in 2 records
- AIN · 2-(acetyloxy)benzoic acid · in 2 records
- MYR · Myristic acid · in 2 records
- OCA · Octanoic acid (caprylic acid) · in 2 records
- ROA · (2R)-3-(3,4-dihydroxyphenyl)-2-{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}propanoic acid · in 2 records
- VRD · ({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic acid · in 2 records
Experiment against prediction
- 6B83 chain B against the predicted model Q9I834: TM-score 0.97, RMSD 0.85 Å
- 6B83 chain B against the predicted model Q9I834: TM-score 0.97, RMSD 0.85 Å
- 6B81 chain A against the predicted model Q9I834: TM-score 0.97, RMSD 0.93 Å
- 6B83 chain A against the predicted model Q9I834: TM-score 0.96, RMSD 0.95 Å
- 6MQD chain A against the predicted model Q9I834: TM-score 0.96, RMSD 0.96 Å
- 6MQD chain A against the predicted model Q9I834: TM-score 0.96, RMSD 0.96 Å
- 6B81 chain B against the predicted model Q9I834: TM-score 0.96, RMSD 1.01 Å
- 6B81 chain B against the predicted model Q9I834: TM-score 0.96, RMSD 1.01 Å
- 4KF3 chain B against the predicted model Q9I834: TM-score 0.96, RMSD 0.99 Å
- 4KF3 chain B against the predicted model Q9I834: TM-score 0.96, RMSD 0.99 Å
Elsewhere
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