UniProt Q9I685
Adenosylhomocysteinase (Q9I685)
Adenosylhomocysteinase (UniProt Q9I685), EC 3.3.1.1: 9 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 75 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9I685
- Protein
- Adenosylhomocysteinase
- EC
- 3.3.1.1
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 75 · 5 records with a druggable one
Structures
10 records of Q9I685 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6F3M | Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa complexed with… | x-ray diffraction | A, B, C, D | NAD, ADN, PO4, K, ZN | 20 (best 0.89) |
| 6F3M | Crystal structure of S-adenosyl-L-homocysteine hydrolase from pseudomonas aeruginosa complexed with… | x-ray diffraction | A, B, C, D | NAD, ADN, PO4, K, ZN | — |
| 6F3N | Crystal structure of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa cocrystallized… | x-ray diffraction | A, B, C, D | K, ZN, PO4, NAD, ADN | 20 (best 0.89) |
| 6F3N | Crystal structure of S-adenosyl-L-homocysteine hydrolase from pseudomonas aeruginosa cocrystallized… | x-ray diffraction | A, B, C, D | K, ZN, PO4, NAD, ADN | — |
| 6F3O | Crystal structure of S-adenosyl-L-homocysteine hydrolase from pseudomonas aeruginosa complexed with… | x-ray diffraction | A, B, C, D | K, PO4, NAD, ADE, ZN | — |
| 6F3P | Crystal structure of S-adenosyl-L-homocysteine hydrolase from pseudomonas aeruginosa in complex… | x-ray diffraction | A, C | NAD, 3AD, K, CL, PO4 | — |
| 6F3Q | Crystal structure of S-adenosyl-L-homocysteine hydrolase from pseudomonas aeruginosa in complex… | x-ray diffraction | A, B, C, D | RB, PO4, NAD, ADE | — |
| 7ZD4 | Crystal structure of Pseudomonas aeruginosa S-adenosyl-L-homocysteine hydrolase soaked with Cu+ ions | x-ray diffraction | A, B, C, D | NAD, ADN, K, BR | 20 (best 0.89) |
| 8CFN | Crystal structure of S-adenosyl-L-homocysteine hydrolase from P. aeruginosa in complex with… | x-ray diffraction | A, C | NAD, K, PO4, RAY, ADE | 11 (best 0.71) |
| Q9I685 | AlphaFold monomer V2.0 prediction for adenosylhomocysteinase (Q9I685) | predicted | A | — | 4 (best 0.72) |
Ligands
- NAD · Nicotinamide-adenine-dinucleotide · in 9 records
- K · Potassium ion · in 8 records
- PO4 · Phosphate ion · in 8 records
- ADN · Adenosine · in 5 records
- ZN · Zinc ion · in 5 records
- ADE · Adenine · in 3 records
- 3AD · 3'-deoxyadenosine · in 1 record
- BR · Bromide ion · in 1 record
- CL · Chloride ion · in 1 record
- RAY · N-(3-fluorophenyl)-2-(2-methoxyethoxy)acetamide · in 1 record
- RB · Rubidium ion · in 1 record
Experiment against prediction
- 6F3N chain D against the predicted model Q9I685: TM-score 0.99, RMSD 0.73 Å
- 6F3N chain D against the predicted model Q9I685: TM-score 0.99, RMSD 0.73 Å
- 6F3O chain D against the predicted model Q9I685: TM-score 0.99, RMSD 0.73 Å
- 6F3Q chain D against the predicted model Q9I685: TM-score 0.99, RMSD 0.74 Å
- 6F3N chain A against the predicted model Q9I685: TM-score 0.99, RMSD 0.77 Å
- 6F3N chain A against the predicted model Q9I685: TM-score 0.99, RMSD 0.77 Å
- 6F3M chain B against the predicted model Q9I685: TM-score 0.99, RMSD 0.77 Å
- 6F3M chain B against the predicted model Q9I685: TM-score 0.99, RMSD 0.77 Å
- 7ZD4 chain A against the predicted model Q9I685: TM-score 0.99, RMSD 0.78 Å
- 6F3O chain A against the predicted model Q9I685: TM-score 0.99, RMSD 0.78 Å
Elsewhere
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