UniProt Q9HC16
DNA dC->dU-editing enzyme APOBEC-3G (Q9HC16)
DNA dC->dU-editing enzyme APOBEC-3G (UniProt Q9HC16), EC 3.5.4.-: 27 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9HC16
- Protein
- DNA dC->dU-editing enzyme APOBEC-3G
- EC
- 3.5.4.-
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 4 · 1 record with a druggable one
Structures
28 records of Q9HC16 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2JYW | Solution structure of C-terminal domain of APOBEC3G | solution nmr | A | — | — |
| 2JYW | Solution structure of C-terminal domain of APOBEC3G | solution nmr | A | — | — |
| 2KBO | Structure, interaction, and real-time monitoring of the enzymatic reaction of wild type APOBEC3G | solution nmr | A | — | — |
| 2KBO | Structure, interaction, and real-time monitoring of the enzymatic reaction of wild type APOBEC3G | solution nmr | A | — | — |
| 2KEM | Extended structure of citidine deaminase domain of APOBEC3G | solution nmr | A | — | — |
| 2KEM | Extended structure of citidine deaminase domain of APOBEC3G | solution nmr | A | — | — |
| 3E1U | The Crystal Structure of the Anti-Viral APOBEC3G Catalytic Domain | x-ray diffraction | A | — | — |
| 3E1U | The crystal structure of the anti-viral APOBEC3G catalytic domain | x-ray diffraction | A | — | — |
| 3IQS | Crystal structure of the anti-viral APOBEC3G catalytic domain | x-ray diffraction | A | — | — |
| 3IQS | Crystal structure of the anti-viral APOBEC3G catalytic domain | x-ray diffraction | A | — | — |
| 3IR2 | Crystal structure of the APOBEC3G catalytic domain | x-ray diffraction | A, B | — | — |
| 3IR2 | Crystal structure of the APOBEC3G catalytic domain | x-ray diffraction | A, B | — | — |
| 3V4J | First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G | x-ray diffraction | A, B | — | — |
| 3V4J | First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G | x-ray diffraction | A, B | — | — |
| 3V4K | First-In-Class Small Molecule Inhibitors of the Single-strand DNA Cytosine Deaminase APOBEC3G | x-ray diffraction | A, B | — | — |
| 3V4K | First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G | x-ray diffraction | A, B | — | — |
| 4ROV | The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode of… | x-ray diffraction | A, B | — | — |
| 4ROV | The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode of… | x-ray diffraction | A, B | — | — |
| 4ROW | The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode of… | x-ray diffraction | A | — | — |
| 4ROW | The crystal structure of novel APOBEC3G CD2 head-to-tail dimer suggests the binding mode of… | x-ray diffraction | A | — | — |
| 5ZVA | APOBEC3F chimeric catalytic domain in complex with DNA(DC9) | x-ray diffraction | A, B | ZN | — |
| 5ZVB | APOBEC3F chimeric catalytic domain in complex with DNA(DT9) | x-ray diffraction | A, B | ZN | — |
| 6BWY | DNA substrate selection by APOBEC3G | x-ray diffraction | A, B, E, G | PO4, ZN | — |
| 6K3J | Solution structure of APOBEC3G-CD2 with ssdna, product a | solution nmr | A | ZN | — |
| 6K3K | Solution structure of APOBEC3G-CD2 with ssDNA, Product B | solution nmr | A | ZN | 4 (best 0.73) |
| 6K3K | Solution structure of APOBEC3G-CD2 with ssdna, product B | solution nmr | A | ZN | — |
| 7UXD | Crystal structure of APOBEC3G Catalytic domain complex with ssDNA containing 2'-deoxy Zebularine. | x-ray diffraction | A | ZN | — |
| Q9HC16 | AlphaFold monomer V2.0 prediction for DNA dc->du-editing enzyme apobec-3G (Q9HC16) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4ROV chain B against the predicted model Q9HC16: TM-score 0.98, RMSD 0.74 Å
- 4ROV chain B against the predicted model Q9HC16: TM-score 0.98, RMSD 0.74 Å
- 5ZVB chain A against the predicted model Q8IUX4: TM-score 0.97, RMSD 1.30 Å
- 5ZVB chain B against the predicted model Q8IUX4: TM-score 0.97, RMSD 1.25 Å
- 4ROV chain A against the predicted model Q9HC16: TM-score 0.97, RMSD 1.13 Å
- 4ROV chain A against the predicted model Q9HC16: TM-score 0.97, RMSD 1.13 Å
- 5ZVA chain B against the predicted model Q8IUX4: TM-score 0.97, RMSD 1.29 Å
- 7UXD chain A against the predicted model Q9HC16: TM-score 0.97, RMSD 1.30 Å
- 3V4J chain A against the predicted model Q9HC16: TM-score 0.96, RMSD 1.04 Å
- 3V4J chain A against the predicted model Q9HC16: TM-score 0.96, RMSD 1.04 Å
Elsewhere
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