UniProt Q9H9Z2
Protein lin-28 homolog A (Q9H9Z2)
Protein lin-28 homolog A (UniProt Q9H9Z2): 9 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9H9Z2
- Protein
- Protein lin-28 homolog A
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 15 · 5 records with a druggable one
Structures
10 records of Q9H9Z2 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2CQF | Solution Structure of the Zinc-finger domain in LIN-28 | solution nmr | A | — | — |
| 2CQF | Solution structure of the zinc-finger domain in lin-28 | solution nmr | A | — | — |
| 2LI8 | The solution structure of the Lin28-ZnF domains bound to AGGAGAU of pre-let-7 miRNA | solution nmr | A | — | — |
| 2LI8 | The solution structure of the LIN28-znf domains bound to aggagau of pre-let-7 miRNA | solution nmr | A | — | — |
| 5UDZ | Human LIN28A in complex with let-7f-1 microRNA pre-element | x-ray diffraction | A, B | ZN | 7 (best 0.58) |
| 5UDZ | Human LIN28A in complex with let-7F-1 microrna pre-element | x-ray diffraction | A, B | ZN | — |
| 8OPS | Human terminal uridylyltransferase 7 (TUT7/ZCCHC6) bound with pre-let7g miRNA and Lin28A - complex 1 | electron microscopy | B | ZN | 3 (best 0.65) |
| 8OPT | Human terminal uridylyltransferase 7 (TUT7/ZCCHC6) bound with pre-let7g miRNA and Lin28A - complex 2 | electron microscopy | B | ZN | 3 (best 0.67) |
| 8OST | Structure of human terminal uridylyltransferase 4 (TUT4, ZCCHC11) in complex with pre-let7g miRNA… | electron microscopy | B | ZN | 1 (best 0.53) |
| Q9H9Z2 | AlphaFold monomer V2.0 prediction for protein lin-28 homolog a (Q9H9Z2) | predicted | A | — | 1 (best 0.62) |
Ligands
- ZN · Zinc ion · in 5 records
Experiment against prediction
- 5UDZ chain A against the predicted model Q9H9Z2: TM-score 0.96, RMSD 1.56 Å
- 5UDZ chain A against the predicted model Q9H9Z2: TM-score 0.96, RMSD 1.56 Å
- 5UDZ chain B against the predicted model Q9H9Z2: TM-score 0.95, RMSD 1.51 Å
- 2LI8 chain A against the predicted model Q9H9Z2: TM-score 0.62, RMSD 1.86 Å
- 2LI8 chain A against the predicted model Q9H9Z2: TM-score 0.62, RMSD 1.86 Å
- 8OST chain B against the predicted model Q9H9Z2: TM-score 0.61, RMSD 1.99 Å
- 8OPS chain B against the predicted model Q9H9Z2: TM-score 0.61, RMSD 1.87 Å
- 8OPT chain B against the predicted model Q9H9Z2: TM-score 0.52, RMSD 2.12 Å
- 2CQF chain A against the predicted model Q9H9Z2: TM-score 0.33, RMSD 3.13 Å
- 2CQF chain A against the predicted model Q9H9Z2: TM-score 0.33, RMSD 3.13 Å
Elsewhere
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