UniProt Q9H999
Pantothenate kinase 3 (Q9H999)
Pantothenate kinase 3 (UniProt Q9H999), EC 2.7.1.33: 31 experimental structures on GenesisL1, 20 ligands bound, 40 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9H999
- Protein
- Pantothenate kinase 3
- EC
- 2.7.1.33
- Experimental structures
- 31
- Predicted models
- 0
- Ligands
- 20
- Pockets
- 40 · 8 records with a druggable one
Structures
31 records of Q9H999 in the MolNFT archive: 31 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2I7P | Crystal structure of human PANK3 in complex with AcCoA | x-ray diffraction | A, B, C, D | — | — |
| 2I7P | Crystal structure of human PANK3 in complex with accoa | x-ray diffraction | A, B, C, D | — | — |
| 3MK6 | Substrate and Inhibitor Binding to Pank | x-ray diffraction | A, B, C, D | — | — |
| 3MK6 | Substrate and inhibitor binding to pank | x-ray diffraction | A, B, C, D | — | — |
| 3SMS | Human Pantothenate kinase 3 in complex with a pantothenate analog | x-ray diffraction | A | — | — |
| 3SMS | Human pantothenate kinase 3 in complex with a pantothenate analog | x-ray diffraction | A | — | — |
| 5KPR | PANK3-amppnp-pantothenate complex | x-ray diffraction | A | MG, ANP, PAU | — |
| 5KPT | PANK3-AMPPNP complex | x-ray diffraction | A | MG, ANP | — |
| 5KPT | PANK3-amppnp complex | x-ray diffraction | A | MG, ANP | — |
| 5KPZ | PANK3-ADP-PhosphoPantothenate complex | x-ray diffraction | A | PAZ, ADP, MG | — |
| 5KPZ | PANK3-ADP-phosphopantothenate complex | x-ray diffraction | A | PAZ, ADP, MG | — |
| 5KQ8 | PANK3-AMPPN complex | x-ray diffraction | A | AN2, MG | — |
| 5KQ8 | PANK3-amppn complex | x-ray diffraction | A | AN2, MG | — |
| 5KQD | PANK3:Palmitoyl-CoA complex | x-ray diffraction | A | PKZ, SO4 | — |
| 5KQD | PANK3:PALMITOYL-CoA complex | x-ray diffraction | A | PKZ, SO4 | — |
| 6B3V | PANK3 complex with compound PZ-2891 | x-ray diffraction | A | ANP, 7DQ | — |
| 6B3V | PANK3 complex with compound pz-2891 | x-ray diffraction | A | ANP, 7DQ | — |
| 6PE6 | PANK3 complex structure with compound PZ-3022 | x-ray diffraction | A | ODG, ANP | — |
| 6PE6 | PANK3 complex structure with compound pz-3022 | x-ray diffraction | A | ODG, ANP | — |
| 6X4J | PANK3 complex structure with compound PZ-2863 | x-ray diffraction | A | MG, ANP, UOM | 5 (best 0.67) |
| 6X4J | PANK3 complex structure with compound pz-2863 | x-ray diffraction | A | MG, ANP, UOM | — |
| 6X4K | PANK3 complex structure with compound pz-2890 | x-ray diffraction | A | UOP, ANP, CL | — |
| 6X4L | PANK3 complex structure with compound PZ-3565 | x-ray diffraction | A | UOS, ANP, MG, CL | 5 (best 0.70) |
| 6X4L | PANK3 complex structure with compound pz-3565 | x-ray diffraction | A | UOS, ANP, MG, CL | — |
| 7UE4 | PANK3 complex structure with compound PZ-3855 | x-ray diffraction | A | ANP, MG, Y89 | 5 (best 0.66) |
| 7UE6 | PANK3 complex structure with compound PZ-3802 | x-ray diffraction | A | NDK, ANP, MG | 5 (best 0.69) |
| 7UEO | PANK3 complex structure with compound PZ-3977 | x-ray diffraction | A | MG, ANP, Y90 | 5 (best 0.69) |
| 7UEP | PANK3 complex structure with compound PZ-3860 | x-ray diffraction | A | ANP, MG, Y93 | 5 (best 0.75) |
| 7UEV | PANK3 complex structure with compound PZ-4200 | x-ray diffraction | A | N0I, ANP, MG, CL | 5 (best 0.69) |
| 7UEX | PANK3 complex structure with compound PZ-4127 | x-ray diffraction | A | MZI, ANP, CL, MG | 5 (best 0.69) |
| Q9H999 | AlphaFold monomer V2.0 prediction for pantothenate kinase 3 (Q9H999) | — | — | — |
Ligands
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 18 records
- MG · Magnesium ion · in 17 records
- CL · Chloride ion · in 5 records
- 7DQ · 6-(4-{[4-(propan-2-yl)phenyl]acetyl}piperazin-1-yl) pyridazine-3-carbonitrile · in 2 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- AN2 · Amp phosphoramidate · in 2 records
- ODG · 6-{4-[(4-cyclopropylphenyl)acetyl]piperazin-1-yl}pyridazine-3-carbonitrile · in 2 records
- PAZ · N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy) butanoyl]-beta-alanine · in 2 records
- PKZ · Palmitoyl-CoA · in 2 records
- SO4 · Sulfate ion · in 2 records
- UOM · 6-(4-{[4-(propan-2-yl)phenyl]acetyl}piperazin-1-yl) pyridine-3-carbonitrile · in 2 records
- UOS · 1-[4-(5-chloropyrazin-2-yl)piperazin-1-yl]-2-[4-(propan-2-yl)phenyl]ethan-1-one · in 2 records
- MZI · 2-(4-{2-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-oxoethyl}anilino)-2-oxoethyl acetate · in 1 record
- N0I · N-(4-{2-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-oxoethyl}phenyl)-N-methylmethanesulfonamide · in 1 record
- NDK · 6-(4-{[5-fluoro-6-(propan-2-yl)pyridin-3-yl]acetyl}piperazin-1-yl)pyridazine-3-carbonitrile · in 1 record
- PAU · Pantothenoic acid · in 1 record
- UOP · 4-(6-cyanopyridazin-3-yl)-N-[4-(propan-2-yl)phenyl]-3, 4-dihydropyrazine-1(2H)-carboxamide · in 1 record
- Y89 · 1-[4-(6-chloropyridazin-3-yl)piperazin-1-yl]-2-(4-cyclopropylphenyl)ethan-1-one · in 1 record
- Y90 · 6-{4-[(4-cyclopropyl-2-fluorophenyl)acetyl]piperazin-1-yl}pyridazine-3-carbonitrile · in 1 record
- Y93 · 1-[(2R)-4-(6-chloropyridazin-3-yl)-2-methylpiperazin-1-yl]-2-(4-cyclopropylphenyl)ethan-1-one · in 1 record
Elsewhere
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