UniProt Q9H479
Fructosamine-3-kinase (Q9H479)
Fructosamine-3-kinase (UniProt Q9H479), EC 2.7.1.171, 2.7.1.172: 7 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 33 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9H479
- Protein
- Fructosamine-3-kinase
- EC
- 2.7.1.171, 2.7.1.172
- Experimental structures
- 7
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 33 · 7 records with a druggable one
Structures
8 records of Q9H479 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8UE1 | Crystal Structure of Human Fructosamine-3-kinase (FN3K) | x-ray diffraction | A | — | 3 (best 0.68) |
| 9CX8 | Crystal structure of Human FN3K in apo-state | x-ray diffraction | A, B | SO4 | 6 (best 0.84) |
| 9CXM | Crystal structure of Human FN3K bound with ATP and DMF | x-ray diffraction | A, B | SO4, ADP, ATP, A1A0O | 5 (best 0.83) |
| 9CXN | Crystal structure of Human FN3K bound with AMPPNP and DMF | x-ray diffraction | A, B | SO4, ANP, A1A0O | 5 (best 0.84) |
| 9CXO | Crystal structure of Human FN3K(D217S) mutant bound with ATP | x-ray diffraction | A, B | SO4, ATP, PO4 | 5 (best 0.85) |
| 9CXV | Crystal structure of Human FN3K bound with ADP and DMF (I) | x-ray diffraction | A, B | SO4, MG, ADP, A1A0O | 5 (best 0.82) |
| 9CXW | Crystal structure of Human FN3K bound with ADP and DMF (II) | x-ray diffraction | A, B | MG, SO4, ADP, A1A0O | 4 (best 0.85) |
| Q9H479 | AlphaFold monomer V2.0 prediction for fructosamine-3-kinase (Q9H479) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 6 records
- A1A0O · 1-deoxy-1-(morpholin-4-yl)-D-fructose · in 4 records
- ADP · Adenosine-5'-diphosphate · in 3 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- MG · Magnesium ion · in 2 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 9CXO chain A against the predicted model Q9H479: TM-score 0.98, RMSD 0.81 Å
- 9CXO chain B against the predicted model Q9H479: TM-score 0.98, RMSD 0.91 Å
- 8UE1 chain A against the predicted model Q9H479: TM-score 0.97, RMSD 1.49 Å
- 9CXV chain B against the predicted model Q9H479: TM-score 0.92, RMSD 1.01 Å
- 9CXM chain B against the predicted model Q9H479: TM-score 0.92, RMSD 1.02 Å
- 9CXN chain B against the predicted model Q9H479: TM-score 0.92, RMSD 1.05 Å
- 9CXM chain A against the predicted model Q9H479: TM-score 0.92, RMSD 1.21 Å
- 9CXW chain A against the predicted model Q9H479: TM-score 0.92, RMSD 1.22 Å
- 9CXW chain B against the predicted model Q9H479: TM-score 0.92, RMSD 1.09 Å
- 9CXV chain A against the predicted model Q9H479: TM-score 0.92, RMSD 1.07 Å
Elsewhere
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