UniProt Q9H228
Sphingosine 1-phosphate receptor 5 (Q9H228)
Sphingosine 1-phosphate receptor 5 (UniProt Q9H228): 4 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9H228
- Protein
- Sphingosine 1-phosphate receptor 5
- Experimental structures
- 4
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 15 · 3 records with a druggable one
Structures
5 records of Q9H228 in the MolNFT archive: 4 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EW1 | Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 5 in complex with Gi protein | electron microscopy | A | J8C | 4 (best 0.85) |
| 7EW1 | Cryo-EM structure of siponimod -bound sphingosine-1-phosphate receptor 5 in complex with gi protein | electron microscopy | A | J8C | — |
| 7YXA | XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608 | x-ray diffraction | A, B | NAG, B2O, OLA | 7 (best 0.75) |
| 7YXA | Xfel crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ono-5430608 | x-ray diffraction | A, B | NAG, B2O, OLA | — |
| Q9H228 | AlphaFold monomer V2.0 prediction for sphingosine 1-phosphate receptor 5 (Q9H228) | predicted | A | — | 4 (best 0.81) |
Ligands
- B2O · 4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid · in 2 records
- J8C · 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl) phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- OLA · Oleic acid · in 2 records
Experiment against prediction
- 7EW1 chain A against the predicted model Q9H228: TM-score 0.91, RMSD 2.18 Å
- 7EW1 chain A against the predicted model Q9H228: TM-score 0.91, RMSD 2.18 Å
- 7YXA chain A against the predicted model Q9H228: TM-score 0.77, RMSD 1.82 Å
- 7YXA chain A against the predicted model Q9H228: TM-score 0.77, RMSD 1.82 Å
- 7YXA chain B against the predicted model Q9H228: TM-score 0.76, RMSD 1.89 Å
- 7YXA chain B against the predicted model Q9H228: TM-score 0.76, RMSD 1.89 Å
- 7YXA chain B against the predicted model P0ABE7: TM-score 0.26, RMSD 1.94 Å
- 7YXA chain B against the predicted model P0ABE7: TM-score 0.26, RMSD 1.94 Å
- 7YXA chain A against the predicted model P0ABE7: TM-score 0.25, RMSD 1.83 Å
- 7YXA chain A against the predicted model P0ABE7: TM-score 0.25, RMSD 1.83 Å
Elsewhere
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