UniProt Q9H204
Mediator of RNA polymerase II transcription subunit 28 (Q9H204)
Mediator of RNA polymerase II transcription subunit 28 (UniProt Q9H204): 14 experimental structures and 1 predicted model on GenesisL1, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9H204
- Protein
- Mediator of RNA polymerase II transcription subunit 28
- Experimental structures
- 14
- Predicted models
- 1
- Pockets
- 17 · 7 records with a druggable one
Structures
15 records of Q9H204 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EMF | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | electron microscopy | 1 | — | 4 (best 0.80) |
| 7EMF | Human mediator (deletion of MED1-idr) in a tail-extended conformation | electron microscopy | 1 | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | e | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | e | — | — |
| 7ENJ | Human Mediator (deletion of MED1-IDR) in a Tail-bent conformation (MED-B) | electron microscopy | 1 | — | 4 (best 0.80) |
| 7ENJ | Human mediator (deletion of MED1-idr) in a tail-bent conformation (med-B) | electron microscopy | 1 | — | — |
| 7LBM | Structure of the human Mediator-bound transcription pre-initiation complex | electron microscopy | o | — | 1 (best 0.81) |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | q | — | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | q | — | — |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | e | — | 1 (best 0.81) |
| 8GXS | PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state | electron microscopy | e | — | — |
| 8T9D | CryoEM structure of TR-TRAP | electron microscopy | W | — | 3 (best 0.89) |
| 8TQW | Structure of human transcriptional Mediator complex | electron microscopy | 1 | — | 2 (best 0.88) |
| 8TRH | The IDRc bound human core Mediator complex | electron microscopy | 1 | — | 2 (best 0.81) |
| Q9H204 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 28… | predicted | A | — | — |
Experiment against prediction
- 7NVR chain q against the predicted model Q9H204: TM-score 0.90, RMSD 1.03 Å
- 7NVR chain q against the predicted model Q9H204: TM-score 0.90, RMSD 1.03 Å
- 8GXQ chain e against the predicted model Q9H204: TM-score 0.83, RMSD 2.19 Å
- 8GXS chain e against the predicted model Q9H204: TM-score 0.83, RMSD 2.19 Å
- 7EMF chain 1 against the predicted model Q9H204: TM-score 0.82, RMSD 2.28 Å
- 7EMF chain 1 against the predicted model Q9H204: TM-score 0.82, RMSD 2.28 Å
- 7ENJ chain 1 against the predicted model Q9H204: TM-score 0.82, RMSD 2.28 Å
- 7ENJ chain 1 against the predicted model Q9H204: TM-score 0.82, RMSD 2.28 Å
- 8TRH chain 1 against the predicted model Q9H204: TM-score 0.82, RMSD 2.33 Å
- 7LBM chain o against the predicted model Q9H204: TM-score 0.82, RMSD 2.37 Å
Elsewhere
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