UniProt Q9H0F6

Sharpin (Q9H0F6)

Sharpin (UniProt Q9H0F6): 5 experimental structures and 1 predicted model on GenesisL1, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: Q9H0F6
Protein: Sharpin
Experimental structures: 5
Predicted models: 1
Pockets: 10 · 2 records with a druggable one

Structures

6 records of Q9H0F6 in the MolNFT archive: 5 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4EMO	Crystal structure of the PH domain of SHARPIN	x-ray diffraction	A, B, C, D	—	—
4EMO	Crystal structure of the pH domain of sharpin	x-ray diffraction	A, B, C, D	—	—
5X0W	Molecular mechanism for the binding between Sharpin and HOIP	x-ray diffraction	B, D, F, H	—	7 (best 0.73)
5X0W	Molecular mechanism for the binding between sharpin and hoip	x-ray diffraction	B, D, F, H	—	—
8K6P	Crystal structure of SHARPIN LTM motif	x-ray diffraction	A, B, C	—	1 (best 0.32)
Q9H0F6	AlphaFold monomer V2.0 prediction for sharpin (Q9H0F6)	predicted	A	—	2 (best 0.61)

Experiment against prediction

4EMO chain A against the predicted model Q9H0F6: TM-score 0.96, RMSD 0.77 Å
4EMO chain A against the predicted model Q9H0F6: TM-score 0.96, RMSD 0.77 Å
5X0W chain B against the predicted model Q9H0F6: TM-score 0.96, RMSD 0.91 Å
5X0W chain B against the predicted model Q9H0F6: TM-score 0.96, RMSD 0.91 Å
4EMO chain B against the predicted model Q9H0F6: TM-score 0.96, RMSD 0.87 Å
4EMO chain B against the predicted model Q9H0F6: TM-score 0.96, RMSD 0.87 Å
5X0W chain F against the predicted model Q9H0F6: TM-score 0.94, RMSD 1.17 Å
5X0W chain F against the predicted model Q9H0F6: TM-score 0.94, RMSD 1.17 Å
8K6P chain A against the predicted model Q9H0F6: TM-score 0.93, RMSD 1.52 Å
5X0W chain D against the predicted model Q9H0F6: TM-score 0.93, RMSD 1.32 Å

Elsewhere

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