UniProt Q9GZV3
High affinity choline transporter 1 (Q9GZV3)
High affinity choline transporter 1 (UniProt Q9GZV3): 12 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 76 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9GZV3
- Protein
- High affinity choline transporter 1
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 76 · 13 records with a druggable one
Structures
13 records of Q9GZV3 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8J74 | Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation… | electron microscopy | A, B | NAG, Y01, AV0, R16, HC6 | 10 (best 0.78) |
| 8J75 | Human high-affinity choline transporter CHT1 in the HC-3-bound outward-facing open conformation… | electron microscopy | A | NAG, HC6 | 4 (best 0.78) |
| 8J76 | Human high-affinity choline transporter CHT1 in the inward-facing apo-open conformation | electron microscopy | A | NAG | 5 (best 0.70) |
| 8J77 | Human high-affinity choline transporter CHT1 in the choline-bound inward-facing occluded… | electron microscopy | A | NAG, CHT | 7 (best 0.71) |
| 8ZQO | Human high-affinity choline transporter CHT1 bound to HC-3 under NaCl condition, with sodium and… | electron microscopy | A | NAG, NA, HC6, CL | 5 (best 0.79) |
| 8ZQP | Human high-affinity choline transporter CHT1 bound to ML352 under NaCl condition, with sodium ion… | electron microscopy | A | NAG, A1AOW, NA | 5 (best 0.76) |
| 8ZQQ | Human high-affinity choline transporter CHT1 bound to choline under NaCl condition, with sodium and… | electron microscopy | A | NAG, CHT, NA, CL | 4 (best 0.71) |
| 8ZQR | Human high-affinity choline transporter CHT1 in apo state under NaCl condition. | electron microscopy | A | NAG | 6 (best 0.73) |
| 9BFI | Cryo-EM structure of human CHT1 in the apo inward-open state | electron microscopy | A | — | 7 (best 0.69) |
| 9BFJ | Cryo-EM structure of human CHT1 in the choline bound state | electron microscopy | A | CHT, CL, NA | 5 (best 0.74) |
| 9BFK | Cryo-EM structure of human CHT1 in the ML352 bound state | electron microscopy | A | A1AOW | 6 (best 0.73) |
| 9BIM | Cryo-EM structure of human CHT1 in the HC-3 bound outward-facing state | electron microscopy | A | HC6 | 4 (best 0.80) |
| Q9GZV3 | AlphaFold monomer V2.0 prediction for high affinity choline transporter 1 (Q9GZV3) | predicted | A | — | 8 (best 0.73) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 8 records
- HC6 · (2S,2'S)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium) · in 4 records
- NA · Sodium ion · in 4 records
- CHT · Choline ion · in 3 records
- CL · Chloride ion · in 3 records
- A1AOW · 4-methoxy-3-[(1-methylpiperidin-4-yl)oxy]-N-{[3-(propan-2-yl)-1,2-oxazol-5-yl]methyl}benzamide · in 2 records
- AV0 · 2-decyl-2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}dodecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside · in 1 record
- R16 · Hexadecane · in 1 record
- Y01 · Cholesterol hemisuccinate · in 1 record
Experiment against prediction
- 9BIM chain A against the predicted model Q9GZV3: TM-score 0.98, RMSD 1.23 Å
- 8J74 chain A against the predicted model Q9GZV3: TM-score 0.98, RMSD 1.31 Å
- 8ZQO chain A against the predicted model Q9GZV3: TM-score 0.97, RMSD 1.45 Å
- 8J75 chain A against the predicted model Q9GZV3: TM-score 0.97, RMSD 1.46 Å
- 8ZQP chain A against the predicted model Q9GZV3: TM-score 0.96, RMSD 1.76 Å
- 9BFJ chain A against the predicted model Q9GZV3: TM-score 0.95, RMSD 2.08 Å
- 9BFK chain A against the predicted model Q9GZV3: TM-score 0.93, RMSD 2.31 Å
- 9BFI chain A against the predicted model Q9GZV3: TM-score 0.93, RMSD 2.37 Å
- 8J77 chain A against the predicted model Q9GZV3: TM-score 0.92, RMSD 2.48 Å
- 8J76 chain A against the predicted model Q9GZV3: TM-score 0.91, RMSD 2.65 Å
Elsewhere
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