UniProt Q9DE46
DNA polymerase alpha catalytic subunit (Q9DE46)
DNA polymerase alpha catalytic subunit (UniProt Q9DE46), EC 2.7.7.7: 6 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 84 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9DE46
- Protein
- DNA polymerase alpha catalytic subunit
- EC
- 2.7.7.7
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 84 · 6 records with a druggable one
Structures
7 records of Q9DE46 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8G99 | Partial auto-inhibitory complex of Xenopus laevis DNA polymerase alpha-primase | electron microscopy | A | ZN | 17 (best 0.85) |
| 8G9L | DNA initiation subcomplex of Xenopus laevis DNA polymerase alpha-primase | electron microscopy | A | DGT, MG | 14 (best 0.78) |
| 8UCU | Partial DNA termination subcomplex of Xenopus laevis DNA polymerase alpha-primase | electron microscopy | A | DGT, MG | 14 (best 0.76) |
| 8UCV | Complete DNA termination subcomplex 1 of Xenopus laevis DNA polymerase alpha-primase | electron microscopy | A | DGT, MG | 13 (best 0.79) |
| 8UCW | Complete DNA termination subcomplex 2 of Xenopus laevis DNA polymerase alpha-primase | electron microscopy | A | DGT, MG | 13 (best 0.77) |
| 8V6H | DNA initiation complex (configuration 2) of Xenopus laevis DNA polymerase alpha-primase | electron microscopy | A | ZN, DGT, MG | 13 (best 0.81) |
| Q9DE46 | AlphaFold monomer V2.0 prediction for DNA polymerase alpha catalytic subunit (Q9DE46) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8UCU chain A against the predicted model Q9DE46: TM-score 0.98, RMSD 1.59 Å
- 8UCW chain A against the predicted model Q9DE46: TM-score 0.98, RMSD 1.61 Å
- 8UCV chain A against the predicted model Q9DE46: TM-score 0.98, RMSD 1.62 Å
- 8G9L chain A against the predicted model Q9DE46: TM-score 0.98, RMSD 1.62 Å
- 8V6H chain A against the predicted model Q9DE46: TM-score 0.82, RMSD 1.98 Å
- 8G99 chain A against the predicted model Q9DE46: TM-score 0.81, RMSD 4.87 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.