UniProt Q9CAJ0
Protein phosphatase 2C 16 (Q9CAJ0)
Protein phosphatase 2C 16 (UniProt Q9CAJ0), EC 3.1.3.16: 54 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 59 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9CAJ0
- Protein
- Protein phosphatase 2C 16
- EC
- 3.1.3.16
- Experimental structures
- 54
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 59 · 16 records with a druggable one
Structures
55 records of Q9CAJ0 in the MolNFT archive: 54 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3KB3 | Crystal structure of abscisic acid-bound PYL2 in complex with HAB1 | x-ray diffraction | B | — | — |
| 3KB3 | Crystal structure of abscisic acid-bound PYL2 in complex with HAB1 | x-ray diffraction | B | — | — |
| 3NMT | Crystal structure of pyrabactin bound abscisic acid receptor PYL2 mutant A93F in complex with type… | x-ray diffraction | B | — | — |
| 3NMT | Crystal structure of pyrabactin bound abscisic acid receptor PYL2 mutant A93F in complex with type… | x-ray diffraction | B | — | — |
| 3QN1 | Crystal structure of the PYR1 Abscisic Acid receptor in complex with the HAB1 type 2C phosphatase… | x-ray diffraction | B | — | — |
| 3QN1 | Crystal structure of the PYR1 abscisic acid receptor in complex with the HAB1 type 2C phosphatase… | x-ray diffraction | B | — | — |
| 3RT0 | Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (ABA) | x-ray diffraction | A, B | — | — |
| 3RT0 | Crystal structure of PYL10-HAB1 complex in the absence of abscisic acid (aba) | x-ray diffraction | A, B | — | — |
| 3UJG | Crystal structure of SnRK2.6 in complex with HAB1 | x-ray diffraction | B | — | — |
| 3UJG | Crystal structure of SNRK2.6 in complex with HAB1 | x-ray diffraction | B | — | — |
| 3ZVU | Structure of the PYR1 His60Pro mutant in complex with the HAB1 phosphatase and Abscisic acid | x-ray diffraction | B | — | — |
| 3ZVU | Structure of the PYR1 HIS60PRO mutant in complex with the HAB1 phosphatase and abscisic acid | x-ray diffraction | B | — | — |
| 4DS8 | Complex structure of abscisic acid receptor PYL3-(+)-ABA-HAB1 in the presence of Mn2+ | x-ray diffraction | B | — | — |
| 4DS8 | Complex structure of abscisic acid receptor PYL3-(+)-aba-HAB1 in the presence of MN2+ | x-ray diffraction | B | — | — |
| 4LA7 | X-ray crystal structure of the PYL2-quinabactin-Hab1 ternary complex | x-ray diffraction | B | — | — |
| 4LA7 | X-ray crystal structure of the PYL2-quinabactin-HAB1 ternary complex | x-ray diffraction | B | — | — |
| 4LG5 | ABA-mimicking ligand QUINABACTIN in complex with ABA receptor PYL2 and PP2C HAB1 | x-ray diffraction | B | — | — |
| 4LG5 | Aba-mimicking ligand quinabactin in complex with aba receptor PYL2 and PP2C HAB1 | x-ray diffraction | B | — | — |
| 4LGA | ABA-mimicking ligand N-(2-OXO-1-PROPYL-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-PHENYLMETHANESULFONAMIDE… | x-ray diffraction | B | — | — |
| 4LGA | Aba-mimicking ligand N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6- yl)-1-phenylmethanesulfonamide… | x-ray diffraction | B | — | — |
| 4LGB | ABA-mimicking ligand N-(1-METHYL-2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)-1-(4-METHYLPHENYL)METHANESUL… | x-ray diffraction | B | — | — |
| 4LGB | Aba-mimicking ligand N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6… | x-ray diffraction | B | — | — |
| 4WVO | An engineered PYR1 mandipropamid receptor in complex with mandipropamid and HAB1 | x-ray diffraction | B | — | — |
| 5JO1 | Crystal structure of phaseic acid-bound abscisic acid receptor PYL3 in complex with type 2C protein… | x-ray diffraction | B | MG | 3 (best 0.84) |
| 5JO1 | Crystal structure of phaseic acid-bound abscisic acid receptor PYL3 in complex with type 2C protein… | x-ray diffraction | B | — | — |
| 5JO2 | Crystal structure of abscisic acid-bound abscisic acid receptor PYL3 in complex with type 2C… | x-ray diffraction | B | MG | — |
| 5JO2 | Crystal structure of abscisic acid-bound abscisic acid receptor PYL3 in complex with type 2C… | x-ray diffraction | B | — | — |
| 5MN0 | Aba receptor from citrus, CSPYL1 | x-ray diffraction | B | MN, CL | — |
| 5MN0 | Aba receptor from citrus, CSPYL1 | x-ray diffraction | B | MN, CL | — |
| 5OR2 | Crystal structures of PYR1/HAB1 in complex with synthetic analogues of abscisic acid | x-ray diffraction | B | MN | — |
| 5OR6 | Crystal structures of PYR1/HAB1 in complex with synthetic analogues of Abscisic Acid | x-ray diffraction | B | MN | 4 (best 0.83) |
| 5OR6 | Crystal structures of PYR1/HAB1 in complex with synthetic analogues of abscisic acid | x-ray diffraction | B | MN | — |
| 5VR7 | ABA-mimicking ligand AMF1alpha in complex with ABA receptor PYL2 and PP2C HAB1 | x-ray diffraction | B | MG | — |
| 5VR7 | Aba-mimicking ligand AMF1ALPHA in complex with aba receptor PYL2 and PP2C HAB1 | x-ray diffraction | B | MG | — |
| 5VRO | ABA-mimicking ligand AMF1beta in complex with ABA receptor PYL2 and PP2C HAB1 | x-ray diffraction | B | A7S, MG | 2 (best 0.86) |
| 5VRO | Aba-mimicking ligand AMF1BETA in complex with aba receptor PYL2 and PP2C HAB1 | x-ray diffraction | B | MG | — |
| 5VS5 | ABA-mimicking ligand AMF2alpha in complex with ABA receptor PYL2 and PP2C HAB1 | x-ray diffraction | B | 9J7, MG | 4 (best 0.85) |
| 5VS5 | Aba-mimicking ligand AMF2ALPHA in complex with aba receptor PYL2 and PP2C HAB1 | x-ray diffraction | B | MG | — |
| 5VSQ | ABA-mimicking ligand AMF2beta in complex with ABA receptor PYL2 and PP2C HAB1 | x-ray diffraction | B | MG | — |
| 5VSQ | Aba-mimicking ligand AMF2BETA in complex with aba receptor PYL2 and PP2C HAB1 | x-ray diffraction | B | MG | — |
| 5VSR | ABA-mimicking ligand AMF4 in complex with ABA receptor PYL2 and PP2C HAB1 | x-ray diffraction | B | AF0, MG | 4 (best 0.86) |
| 5VSR | Aba-mimicking ligand AMF4 in complex with aba receptor PYL2 and PP2C HAB1 | x-ray diffraction | B | MG | — |
| 5VT7 | ABA-mimicking ligand AMC1beta in complex with ABA receptor PYL2 and PP2C HAB1 | x-ray diffraction | B | A1C, MG | 4 (best 0.86) |
| 5VT7 | Aba-mimicking ligand AMC1BETA in complex with aba receptor PYL2 and PP2C HAB1 | x-ray diffraction | B | MG | — |
| 6ZUC | X-RAY CRYSTAL STRUCTURE OF THE CsPYL1-Lig1-HAB1 TERNARY COMPLEX | x-ray diffraction | B | MN, CL | 3 (best 0.84) |
| 6ZUC | X-ray crystal structure of the CSPYL1-LIG1-HAB1 ternary complex | x-ray diffraction | B | MN, CL | — |
| 7AVW | X-RAY CRYSTAL STRUCTURE OF THE CsPYL1-iSB07-HAB1 TERNARY COMPLEX | x-ray diffraction | B | MN, CL | 5 (best 0.85) |
| 8AY3 | X-RAY CRYSTAL STRUCTURE OF THE CsPYL1-iSB9-HAB1 TERNARY COMPLEX | x-ray diffraction | B | MN, CL | 4 (best 0.85) |
| 8AY6 | X-RAY CRYSTAL STRUCTURE OF THE CsPYL1(V112L, T135L,F137I, T153I, V168A)-SB-HAB1 TERNARY COMPLEX | x-ray diffraction | B | MN, CL | 3 (best 0.85) |
| 8AY7 | X-RAY CRYSTAL STRUCTURE OF THE CsPYL1(V112L, T135L,F137I, T153I, V168A)-iSB7-HAB1 TERNARY COMPLEX | x-ray diffraction | B | MN, CL | 5 (best 0.85) |
| 8AY8 | X-RAY CRYSTAL STRUCTURE OF THE CsPYL1(V112L, T135L,F137I, T153I, V168A)-iSB9-HAB1 TERNARY COMPLEX | x-ray diffraction | B | MN, CL | 3 (best 0.85) |
| 8AY9 | X-RAY CRYSTAL STRUCTURE OF THE CsPYL1(V112L, T135L,F137I, T153I, V168A)-ABA-HAB1 TERNARY COMPLEX | x-ray diffraction | B | MN, CL | 5 (best 0.84) |
| 8AYA | X-RAY CRYSTAL STRUCTURE OF THE CsPYL1-A10-HAB1 TERNARY COMPLEX | x-ray diffraction | B | A1O, MN, CL | 4 (best 0.85) |
| 8EY0 | Structure of an orthogonal PYR1*:HAB1* chemical-induced dimerization module in complex with… | x-ray diffraction | B | 3UZ | 3 (best 0.86) |
| Q9CAJ0 | AlphaFold monomer V2.0 prediction for protein phosphatase 2C 16 (Q9CAJ0) | predicted | A | — | 3 (best 0.69) |
Ligands
- MG · Magnesium ion · in 14 records
- MN · Manganese (II) ion · in 14 records
- CL · Chloride ion · in 11 records
- 3UZ · (2S)-2-(4-chlorophenyl)-N-{2-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]ethyl}-2-(prop-2-yn-1-yloxy)ethanamide · in 1 record
- 9J7 · 1-(2,3-difluoro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2, 3,4-tetrahydroquinolin-6-yl)methanesulfonamide · in 1 record
- A1C · 1-(3-chloro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide · in 1 record
- A1O · Quinabactin · in 1 record
- A7S · 1-(3-fluoro-4-methylphenyl)-N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)methanesulfonamide · in 1 record
- AF0 · N-(2-oxo-1-propyl-1,2,3,4-tetrahydroquinolin-6-yl)-1-(2,3,5,6-tetrafluoro-4-methylphenyl)methanesulfonamide · in 1 record
Experiment against prediction
- 3ZVU chain B against the predicted model Q9CAJ0: TM-score 1.00, RMSD 0.43 Å
- 3ZVU chain B against the predicted model Q9CAJ0: TM-score 1.00, RMSD 0.43 Å
- 4WVO chain B against the predicted model Q9CAJ0: TM-score 0.99, RMSD 0.47 Å
- 5JO1 chain B against the predicted model Q9CAJ0: TM-score 0.99, RMSD 0.48 Å
- 5JO1 chain B against the predicted model Q9CAJ0: TM-score 0.99, RMSD 0.48 Å
- 4LA7 chain B against the predicted model Q9CAJ0: TM-score 0.99, RMSD 0.50 Å
- 4LA7 chain B against the predicted model Q9CAJ0: TM-score 0.99, RMSD 0.50 Å
- 5VT7 chain B against the predicted model Q9CAJ0: TM-score 0.99, RMSD 0.50 Å
- 5VT7 chain B against the predicted model Q9CAJ0: TM-score 0.99, RMSD 0.50 Å
- 5VRO chain B against the predicted model Q9CAJ0: TM-score 0.99, RMSD 0.52 Å
Elsewhere
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