UniProt Q9BUE0
Mediator of RNA polymerase II transcription subunit 18 (Q9BUE0)
Mediator of RNA polymerase II transcription subunit 18 (UniProt Q9BUE0): 9 experimental structures and 1 predicted model on GenesisL1, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9BUE0
- Protein
- Mediator of RNA polymerase II transcription subunit 18
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 5 · 3 records with a druggable one
Structures
10 records of Q9BUE0 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EMF | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | electron microscopy | R | — | 1 (best 0.73) |
| 7EMF | Human mediator (deletion of MED1-idr) in a tail-extended conformation | electron microscopy | R | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | r | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | r | — | — |
| 7ENJ | Human mediator (deletion of MED1-idr) in a tail-bent conformation (med-B) | electron microscopy | R | — | — |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | e | — | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | e | — | — |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | r | — | 1 (best 0.81) |
| 8TQW | Structure of human transcriptional Mediator complex | electron microscopy | R | — | 3 (best 0.87) |
| Q9BUE0 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 18… | predicted | A | — | — |
Experiment against prediction
- 7EMF chain R against the predicted model Q9BUE0: TM-score 0.97, RMSD 1.11 Å
- 7EMF chain R against the predicted model Q9BUE0: TM-score 0.97, RMSD 1.11 Å
- 7ENJ chain R against the predicted model Q9BUE0: TM-score 0.97, RMSD 1.11 Å
- 7ENC chain r against the predicted model Q9BUE0: TM-score 0.96, RMSD 1.13 Å
- 8GXQ chain r against the predicted model Q9BUE0: TM-score 0.96, RMSD 1.20 Å
- 7NVR chain e against the predicted model Q9BUE0: TM-score 0.95, RMSD 1.14 Å
- 7NVR chain e against the predicted model Q9BUE0: TM-score 0.95, RMSD 1.14 Å
- 7ENA chain r against the predicted model Q9BUE0: TM-score 0.90, RMSD 1.45 Å
- 8TQW chain R against the predicted model Q9BUE0: TM-score 0.89, RMSD 1.95 Å
Elsewhere
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