UniProt Q99JB6

Forkhead box protein P3 (Q99JB6)

Forkhead box protein P3 (UniProt Q99JB6): 4 experimental structures and 1 predicted model on GenesisL1, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: Q99JB6
Protein: Forkhead box protein P3
Experimental structures: 4
Predicted models: 1
Pockets: 26 · 2 records with a druggable one

Structures

5 records of Q99JB6 in the MolNFT archive: 4 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4I1L	Structural and Biological Features of FOXP3 Dimerization Relevant to Regulatory T Cell Function	x-ray diffraction	A	—	—
4I1L	Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function	x-ray diffraction	A	—	—
8SRO	FoxP3 tetramer on TTTG repeats	electron microscopy	A, D, B, C	—	6 (best 0.72)
8SRP	FoxP3 forms Ladder-like multimer to bridge TTTG repeats	electron microscopy	A, I, J, H, G, F, E, D, C, B	—	20 (best 0.73)
Q99JB6	AlphaFold monomer V2.0 prediction for forkhead box protein P3 (Q99JB6)	predicted	A	—	—

Experiment against prediction

8SRP chain C against the predicted model Q99JB6: TM-score 0.95, RMSD 0.85 Å
8SRP chain A against the predicted model Q99JB6: TM-score 0.95, RMSD 0.91 Å
8SRO chain A against the predicted model Q99JB6: TM-score 0.94, RMSD 0.96 Å
8SRO chain C against the predicted model Q99JB6: TM-score 0.94, RMSD 0.95 Å
8SRP chain J against the predicted model Q99JB6: TM-score 0.94, RMSD 0.97 Å
8SRP chain B against the predicted model Q99JB6: TM-score 0.94, RMSD 1.00 Å
8SRP chain I against the predicted model Q99JB6: TM-score 0.94, RMSD 0.97 Å
8SRP chain H against the predicted model Q99JB6: TM-score 0.94, RMSD 0.99 Å
8SRO chain B against the predicted model Q99JB6: TM-score 0.94, RMSD 1.01 Å
8SRP chain G against the predicted model Q99JB6: TM-score 0.93, RMSD 1.01 Å

Elsewhere

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