UniProt Q99AU2
HCV Polymerase (Q99AU2)
HCV Polymerase (UniProt Q99AU2): 34 experimental structures on GenesisL1, 2 ligands bound, 23 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q99AU2
- Protein
- HCV Polymerase
- Experimental structures
- 34
- Predicted models
- 0
- Ligands
- 2
- Pockets
- 23 · 2 records with a druggable one
Structures
34 records of Q99AU2 in the MolNFT archive: 34 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2D3U | X-ray crystal structure of hepatitis C virus RNA dependent RNA polymerase in complex with… | x-ray diffraction | A, B | — | — |
| 2D3U | X-ray crystal structure of hepatitis C virus RNA dependent RNA polymerase in complex with… | x-ray diffraction | A, B | — | — |
| 2D3Z | X-ray crystal structure of hepatitis C virus RNA-dependent RNA polymerase in complex with… | x-ray diffraction | A, B | — | — |
| 2D3Z | X-ray crystal structure of hepatitis C virus RNA-dependent RNA polymerase in complex with… | x-ray diffraction | A, B | — | — |
| 2D41 | X-ray crystal structure of hepatitis C virus RNA-dependent RNA polymerase in complex with… | x-ray diffraction | A, B | — | — |
| 2D41 | X-ray crystal structure of hepatitis C virus RNA-dependent RNA polymerase in complex with… | x-ray diffraction | A, B | — | — |
| 2GC8 | Structure of a Proline Sulfonamide Inhibitor Bound to HCV NS5b Polymerase | x-ray diffraction | A, B | — | — |
| 2GC8 | Structure of a proline sulfonamide inhibitor bound to HCV NS5B polymerase | x-ray diffraction | A, B | — | — |
| 2IJN | Isothiazoles as active-site inhibitors of HCV NS5B polymerase | x-ray diffraction | A, B | — | — |
| 2IJN | Isothiazoles as active-site inhibitors of HCV NS5B polymerase | x-ray diffraction | A, B | — | — |
| 2QE2 | Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor | x-ray diffraction | A, B | — | — |
| 2QE2 | Structure of HCV NS5B bound to an anthranilic acid inhibitor | x-ray diffraction | A, B | — | — |
| 2QE5 | Structure of HCV NS5B Bound to an Anthranilic Acid Inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 2QE5 | Structure of HCV NS5B bound to an anthranilic acid inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 2ZKU | Structure of hepatitis C virus NS5B polymerase in a new crystal form | x-ray diffraction | A, B, C, D | — | — |
| 2ZKU | Structure of hepatitis C virus NS5B polymerase in a new crystal form | x-ray diffraction | A, B, C, D | — | — |
| 3CWJ | Crystal structure of hcv ns5b polymerase with a novel pyridazi inhibitor | x-ray diffraction | A, B | — | — |
| 3CWJ | Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor | x-ray diffraction | A, B | — | — |
| 3HHK | HCV NS5b polymerase complex with a substituted benzothiadizine | x-ray diffraction | A, B | — | — |
| 3HHK | HCV NS5B polymerase complex with a substituted benzothiadizine | x-ray diffraction | A, B | — | — |
| 3O8B | Visualizing ATP-dependent RNA Translocation by the NS3 Helicase from HCV | x-ray diffraction | A, B | — | — |
| 3O8B | Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV | x-ray diffraction | A, B | — | — |
| 3O8C | Visualizing ATP-dependent RNA Translocation by the NS3 Helicase from HCV | x-ray diffraction | A, B | — | — |
| 3O8C | Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV | x-ray diffraction | A, B | — | — |
| 3O8D | Visualizing ATP-dependent RNA Translocation by the NS3 Helicase from HCV | x-ray diffraction | A, B | — | — |
| 3O8D | Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV | x-ray diffraction | A, B | — | — |
| 3O8R | Visualizing ATP-dependent RNA Translocation by the NS3 Helicase from HCV | x-ray diffraction | A, B | — | — |
| 3O8R | Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV | x-ray diffraction | A, B | — | — |
| 3UDL | 3-heterocyclyl quinolone bound to HCV NS5B | x-ray diffraction | A, B, C, D | — | — |
| 3UDL | 3-heterocyclyl quinolone bound to HCV NS5B | x-ray diffraction | A, B, C, D | — | — |
| 6MVK | HCV NS5B 1b N316 bound to Compound 18 | x-ray diffraction | A, B | K4J | 11 (best 0.81) |
| 6MVK | HCV NS5B 1B N316 bound to compound 18 | x-ray diffraction | A, B | K4J | — |
| 6MVQ | HCV NS5B 1b N316 bound to Compound 31 | x-ray diffraction | A, B | K4M | 12 (best 0.81) |
| 6MVQ | HCV NS5B 1B N316 bound to compound 31 | x-ray diffraction | A, B | K4M | — |
Ligands
- K4J · (4-{(4S)-3-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]-2-oxo-1,3-oxazolidin-4-yl}-2-fluorophenyl)boronic acid · in 2 records
- K4M · (4-{1-[5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)-1-benzofuran-6-yl]-1H-1,2,4-triazol-5-yl}-2-fluorophenyl)boronic acid · in 2 records
Elsewhere
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