UniProt Q99685
Monoglyceride lipase (Q99685)
Monoglyceride lipase (UniProt Q99685), EC 3.1.1.23: 12 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q99685
- Protein
- Monoglyceride lipase
- EC
- 3.1.1.23
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 6 · 3 records with a druggable one
Structures
13 records of Q99685 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3HJU | Crystal structure of human monoglyceride lipase | x-ray diffraction | A, B | — | — |
| 3HJU | Crystal structure of human monoglyceride lipase | x-ray diffraction | A, B | — | — |
| 4UUQ | Crystal structure of human mono-glyceride lipase in complex with SAR127303 | x-ray diffraction | A, B | — | — |
| 4UUQ | Crystal structure of human mono-glyceride lipase in complex with SAR127303 | x-ray diffraction | A, B | — | — |
| 5ZUN | Crystal structure of human monoacylglycerol lipase in complex with compound 3l | x-ray diffraction | A | 9JX, CL | — |
| 5ZUN | Crystal structure of human monoacylglycerol lipase in complex with compound 3L | x-ray diffraction | A | 9JX, CL | — |
| 6AX1 | Structure of human monoacylglycerol lipase bound to a covalent inhibitor | x-ray diffraction | A, B | C0S | 4 (best 0.75) |
| 6AX1 | Structure of human monoacylglycerol lipase bound to a covalent inhibitor | x-ray diffraction | A, B | C0S | — |
| 6BQ0 | Structure of human monoacylglycerol lipase bound to a covalent inhibitor | x-ray diffraction | A, B | E3A | — |
| 7PRM | Crystal structure of human monoglyceride lipase with compound 13 | x-ray diffraction | A | 81I | 1 (best 0.78) |
| 7PRM | Crystal structure of human monoglyceride lipase with compound 13 | x-ray diffraction | A | 81I | — |
| 8PTR | COMPLEX CRYSTAL STRUCTURE OF MUTANT HUMAN MONOGLYCERIDE LIPASE WITH COMPOUND 5r | x-ray diffraction | A | EFH | 1 (best 0.69) |
| Q99685 | AlphaFold monomer V2.0 prediction for monoglyceride lipase (Q99685) | predicted | A | — | — |
Ligands
- 81I · (4~{R})-1-[4-(4-fluorophenyl)phenyl]-4-[4-(furan-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one · in 2 records
- 9JX · (4R)-1-(2'-chloro[1,1'-biphenyl]-3-yl)-4-[4-(1,3-thiazole-2-carbonyl)piperazin-1-yl]pyrrolidin-2-one · in 2 records
- C0S · 1,1,1,3,3,3-hexafluoropropan-2-yl 3-(3-phenyl-1,2,4-oxadiazol-5-yl)azetidine-1-carboxylate · in 2 records
- CL · Chloride ion · in 2 records
- E3A · 1-({(1R,5S,6R)-6-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]-3-azabicyclo[3.1.0]hexane-3-carbonyl}oxy)pyrrolidine-2,5-dione · in 1 record
- EFH · (3~{R},4~{S})-4-(1,3-benzodioxol-5-yl)-1-[1-(benzotriazol-1-ylcarbonyl)piperidin-4-yl]-3-(3-fluorophenyl)azetidin-2-one · in 1 record
Experiment against prediction
- 5ZUN chain A against the predicted model Q99685: TM-score 1.00, RMSD 0.40 Å
- 5ZUN chain A against the predicted model Q99685: TM-score 1.00, RMSD 0.40 Å
- 7PRM chain A against the predicted model Q99685: TM-score 0.99, RMSD 0.84 Å
- 7PRM chain A against the predicted model Q99685: TM-score 0.99, RMSD 0.84 Å
- 8PTR chain A against the predicted model Q99685: TM-score 0.98, RMSD 1.05 Å
- 6BQ0 chain B against the predicted model Q99685: TM-score 0.97, RMSD 1.20 Å
- 6AX1 chain B against the predicted model Q99685: TM-score 0.97, RMSD 1.22 Å
- 6AX1 chain B against the predicted model Q99685: TM-score 0.97, RMSD 1.22 Å
- 4UUQ chain A against the predicted model Q99685: TM-score 0.97, RMSD 1.23 Å
- 4UUQ chain A against the predicted model Q99685: TM-score 0.97, RMSD 1.23 Å
Elsewhere
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