UniProt Q99613
Eukaryotic translation initiation factor 3 subunit C (Q99613)
Eukaryotic translation initiation factor 3 subunit C (UniProt Q99613): 13 experimental structures and 1 predicted model on GenesisL1, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q99613
- Protein
- Eukaryotic translation initiation factor 3 subunit C
- Experimental structures
- 13
- Predicted models
- 1
- Pockets
- 19 · 9 records with a druggable one
Structures
14 records of Q99613 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6YBD | Structure of a human 48S translational initiation complex - EIF3 | electron microscopy | y | — | — |
| 6YBW | Structure of a human 48S translational initiation complex - 40S body | electron microscopy | y | — | — |
| 6YBW | Structure of a human 48S translational initiation complex - 40S body | electron microscopy | y | — | — |
| 6ZON | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1 | electron microscopy | C | — | 2 (best 0.84) |
| 7A09 | Structure of a human ABCE1-bound 43S pre-initiation complex - State III | electron microscopy | C | — | — |
| 7QP6 | Structure of the human 48S initiation complex in open state (h48S AUG open) | electron microscopy | y | — | 1 (best 0.85) |
| 7QP7 | Structure of the human 48S initiation complex in closed state (h48S AUG closed) | electron microscopy | y | — | 2 (best 0.85) |
| 8OZ0 | Structure of a human 48S translation initiation complex with eIF4F and eIF4A | electron microscopy | J | — | 1 (best 0.85) |
| 8PJ1 | Structure of human 48S translation initiation complex in open codon scanning state (48S-1) | electron microscopy | y | — | 2 (best 0.85) |
| 8PJ6 | Structure of human 48S translation initiation complex with initiator tRNA, eIF1A and eIF3… | electron microscopy | y | — | 2 (best 0.85) |
| 8PPL | MERS-CoV Nsp1 bound to the human 43S pre-initiation complex | electron microscopy | Iy | — | 2 (best 0.86) |
| 8RG0 | Structure of human eIF3 core from closed 48S translation initiation complex | electron microscopy | y | — | 4 (best 0.87) |
| 8XXN | Cryo-EM structure of the human 43S ribosome with PDCD4 | electron microscopy | 3C | — | 3 (best 0.86) |
| Q99613 | AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 3 subunit C (Q99613) | predicted | A | — | — |
Experiment against prediction
- 8RG0 chain y against the predicted model Q99613: TM-score 0.96, RMSD 1.69 Å
- 6YBD chain y against the predicted model Q99613: TM-score 0.96, RMSD 1.72 Å
- 8PJ6 chain y against the predicted model Q99613: TM-score 0.96, RMSD 1.71 Å
- 8PPL chain Iy against the predicted model Q99613: TM-score 0.90, RMSD 2.48 Å
- 6ZON chain C against the predicted model Q99613: TM-score 0.83, RMSD 1.39 Å
- 8XXN chain 3C against the predicted model Q99613: TM-score 0.83, RMSD 1.45 Å
- 7A09 chain C against the predicted model Q99613: TM-score 0.81, RMSD 1.72 Å
- 7QP7 chain y against the predicted model Q99613: TM-score 0.80, RMSD 1.94 Å
- 8OZ0 chain J against the predicted model Q99613: TM-score 0.78, RMSD 2.99 Å
- 7QP6 chain y against the predicted model Q99613: TM-score 0.76, RMSD 2.71 Å
Elsewhere
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