UniProt Q99527
G-protein coupled estrogen receptor 1 (Q99527)
G-protein coupled estrogen receptor 1 (UniProt Q99527): 5 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 25 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q99527
- Protein
- G-protein coupled estrogen receptor 1
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 25 · 5 records with a druggable one
Structures
6 records of Q99527 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8XOF | Cryo-EM structure of Lys05 bound GPR30-Gq complex structure | electron microscopy | R | A1LVW | 5 (best 0.73) |
| 8XOG | Cryo-EM structure of apo-GPR30-Gq complex structure | electron microscopy | R | — | 4 (best 0.72) |
| 8XOH | Cryo-EM structure of GPR30-Gq complex structure in the presence of E2 | electron microscopy | R | — | 5 (best 0.76) |
| 8XOI | Cryo-EM structure of GPR30-Gq complex structure in the presence of fulvestrant | electron microscopy | R | — | 4 (best 0.76) |
| 8XOJ | Cryo-EM structure of GPR30-Gq complex structure in the presence of G-1 | electron microscopy | R | — | 7 (best 0.75) |
| Q99527 | AlphaFold monomer V2.0 prediction for G-protein coupled estrogen receptor 1 (Q99527) | predicted | A | — | — |
Ligands
- A1LVW · Lys01 · in 1 record
Experiment against prediction
- 8XOI chain R against the predicted model Q99527: TM-score 0.88, RMSD 2.63 Å
- 8XOH chain R against the predicted model Q99527: TM-score 0.88, RMSD 2.66 Å
- 8XOJ chain R against the predicted model Q99527: TM-score 0.88, RMSD 2.72 Å
- 8XOG chain R against the predicted model Q99527: TM-score 0.87, RMSD 2.76 Å
- 8XOF chain R against the predicted model Q99527: TM-score 0.87, RMSD 2.73 Å
Elsewhere
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