UniProt Q980T8
DNA ligase (Q980T8)
DNA ligase (UniProt Q980T8), EC 6.5.1.1: 8 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q980T8
- Protein
- DNA ligase
- EC
- 6.5.1.1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 12 · 1 record with a druggable one
Structures
9 records of Q980T8 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2HIV | ATP-dependent DNA ligase from S. solfataricus | x-ray diffraction | A | — | — |
| 2HIV | ATP-dependent DNA ligase from S. solfataricus | x-ray diffraction | A | — | — |
| 2HIX | ATP dependent DNA ligase from S. solfataricus bound to ATP | x-ray diffraction | A | — | — |
| 2HIX | ATP dependent DNA ligase from S. solfataricus bound to ATP | x-ray diffraction | A | — | — |
| 7RPO | Archaeal DNA ligase and heterotrimeric PCNA in complex with non-ligatable DNA | electron microscopy | E | MN, AMP | 12 (best 0.82) |
| 7RPO | Archaeal DNA ligase and heterotrimeric PCNA in complex with non- ligatable DNA | electron microscopy | E | MN, AMP | — |
| 7RPW | Archaeal DNA ligase and heterotrimeric PCNA in complex with adenylated DNA | electron microscopy | E | MN | — |
| 7RPX | Archaeal DNA ligase and heterotrimeric PCNA in complex with end-joined DNA | electron microscopy | E | MN | — |
| Q980T8 | AlphaFold monomer V2.0 prediction for DNA ligase (Q980T8) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7RPO chain E against the predicted model Q980T8: TM-score 0.90, RMSD 2.67 Å
- 7RPO chain E against the predicted model Q980T8: TM-score 0.90, RMSD 2.67 Å
- 7RPW chain E against the predicted model Q980T8: TM-score 0.89, RMSD 2.93 Å
- 2HIV chain A against the predicted model Q980T8: TM-score 0.77, RMSD 3.93 Å
- 2HIV chain A against the predicted model Q980T8: TM-score 0.77, RMSD 3.93 Å
- 2HIX chain A against the predicted model Q980T8: TM-score 0.76, RMSD 3.94 Å
- 2HIX chain A against the predicted model Q980T8: TM-score 0.76, RMSD 3.94 Å
- 7RPX chain E against the predicted model Q980T8: TM-score 0.66, RMSD 3.46 Å
Elsewhere
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