UniProt Q96S44
EKC/KEOPS complex subunit TP53RK (Q96S44)
EKC/KEOPS complex subunit TP53RK (UniProt Q96S44), EC 2.7.11.1, 3.6.-.-: 5 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q96S44
- Protein
- EKC/KEOPS complex subunit TP53RK
- EC
- 2.7.11.1, 3.6.-.-
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 40 · 5 records with a druggable one
Structures
6 records of Q96S44 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6WQX | Human PRPK-TPRKB complex | x-ray diffraction | C, D | ANP, MG | 7 (best 0.63) |
| 6WQX | Human prpk-tprkb complex | x-ray diffraction | C, D | ANP, MG | — |
| 7SZA | Crystal Structure Analysis of human PRPK complex with a compound | x-ray diffraction | A, C | DUI | 11 (best 0.58) |
| 7SZB | Crystal Structure Analysis of human PRPK complex with a compound | x-ray diffraction | A, C | DQ4 | 10 (best 0.62) |
| 7SZD | Crystal Structure Analysis of human PRPK complex with a compound | x-ray diffraction | A, C | DVO | 10 (best 0.60) |
| Q96S44 | AlphaFold monomer V2.0 prediction for EKC/KEOPS complex subunit TP53RK (Q96S44) | predicted | A | — | 2 (best 0.61) |
Ligands
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- MG · Magnesium ion · in 2 records
- DQ4 · 5-amino-2-[(3R)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione · in 1 record
- DUI · 4-amino-2-[(3R)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione · in 1 record
- DVO · 2-[(3R)-3-methyl-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid · in 1 record
Experiment against prediction
- 7SZB chain C against the predicted model Q96S44: TM-score 0.97, RMSD 1.08 Å
- 7SZA chain C against the predicted model Q96S44: TM-score 0.97, RMSD 1.09 Å
- 7SZB chain A against the predicted model Q96S44: TM-score 0.96, RMSD 1.21 Å
- 7SZD chain A against the predicted model Q96S44: TM-score 0.96, RMSD 1.18 Å
- 6WQX chain C against the predicted model Q96S44: TM-score 0.96, RMSD 1.31 Å
- 6WQX chain C against the predicted model Q96S44: TM-score 0.96, RMSD 1.31 Å
- 7SZA chain A against the predicted model Q96S44: TM-score 0.96, RMSD 1.23 Å
- 7SZD chain C against the predicted model Q96S44: TM-score 0.95, RMSD 1.23 Å
- 6WQX chain D against the predicted model Q96S44: TM-score 0.95, RMSD 1.40 Å
- 6WQX chain D against the predicted model Q96S44: TM-score 0.95, RMSD 1.40 Å
Elsewhere
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