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UniProt Q96S37

Solute carrier family 22 member 12 (Q96S37)

Solute carrier family 22 member 12 (UniProt Q96S37): 9 experimental structures on GenesisL1, 5 ligands bound, 34 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt
Q96S37
Protein
Solute carrier family 22 member 12
Experimental structures
9
Predicted models
0
Ligands
5
Pockets
34 · 8 records with a druggable one

Structures

9 records of Q96S37 in the MolNFT archive: 9 experimental, 0 predicted.

EntryTitleMethodChainsLigandsPockets
8WJGCryo-EM structure of URAT1(R477S)electron microscopyA—5 (best 0.82)
8WJQCryo-EM structure of URAT1(R477S)-Urate complexelectron microscopyAURC5 (best 0.83)
9B1GHuman urate transporter 1 URAT1 in complex with dotinuradelectron microscopyANAG, A1AIK3 (best 0.79)
9B1IHuman urate transporter 1 URAT1 in complex with verinuradelectron microscopyANAG, A1AIJ5 (best 0.79)
9B1MPyrazinoate bound human URAT1 in the inward-facing state (site1)electron microscopyANAG, VGL5 (best 0.78)
9JDVHuman URAT1 bound with Uric acidelectron microscopyAURC4 (best 0.80)
9JDYHuman URAT1 bound with verinuradelectron microscopyAA1AIJ4 (best 0.83)
9JE1Human URAT1 bound to dotinuradelectron microscopyAA1AIK3 (best 0.82)
Q96S37AlphaFold monomer V2.0 prediction for solute carrier family 22 member 12 (Q96S37)———

Ligands

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
  • A1AIJ · verinurad · in 2 records
  • A1AIK · dotinurad · in 2 records
  • URC · Uric acid · in 2 records
  • VGL · Pyrazine-2-carboxylic acid · in 1 record

Elsewhere

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