UniProt Q96LA8
Protein arginine N-methyltransferase 6 (Q96LA8)
Protein arginine N-methyltransferase 6 (UniProt Q96LA8), EC 2.1.1.319: 20 experimental structures and 1 predicted model on GenesisL1, 9 ligands bound, 2 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q96LA8
- Protein
- Protein arginine N-methyltransferase 6
- EC
- 2.1.1.319
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 9
- Pockets
- 2 · 1 record with a druggable one
Structures
21 records of Q96LA8 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4HC4 | Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae) | x-ray diffraction | A | — | — |
| 4HC4 | Human HMT1 hnrnp methyltransferase-like protein 6 (S. cerevisiae) | x-ray diffraction | A | — | — |
| 4QPP | The Crystal Structure of Human HMT1 hnRNP methyltransferase-like protein 6 in complex with compound… | x-ray diffraction | A, B, C | — | — |
| 4QPP | The crystal structure of human HMT1 hnrnp methyltransferase-like protein 6 in complex with compound… | x-ray diffraction | A, B, C | — | — |
| 4QQK | Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae) with GMS | x-ray diffraction | A | — | — |
| 4QQK | Human HMT1 hnrnp methyltransferase-like protein 6 (S. cerevisiae) with gms | x-ray diffraction | A | — | — |
| 4Y2H | Crystal structure of human protein arginine methyltransferase PRMT6 bound to SAH and an aryl… | x-ray diffraction | A, B | — | — |
| 4Y2H | Crystal structure of human protein arginine methyltransferase PRMT6 bound to sah and an aryl… | x-ray diffraction | A, B | — | — |
| 4Y30 | Crystal structure of human protein arginine methyltransferase PRMT6 bound to SAH and EPZ020411 | x-ray diffraction | A, B | — | — |
| 4Y30 | Crystal structure of human protein arginine methyltransferase PRMT6 bound to sah and EPZ020411 | x-ray diffraction | A, B | — | — |
| 5E8R | Human HMT1 hnrnp methyltransferase-like protein 6 (S. cerevisiae) | x-ray diffraction | A, B | — | — |
| 5EGS | Human PRMT6 with bound fragment-type inhibitor | x-ray diffraction | A, B, C, D | 5NR | — |
| 5EGS | Human PRMT6 with bound fragment-type inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 5HZM | Human HMT1 hnRNP methyltransferase-like protein 6 (S. cerevisiae) | x-ray diffraction | A | SAH, UNX | 2 (best 0.63) |
| 5HZM | Human HMT1 hnrnp methyltransferase-like protein 6 (S. cerevisiae) | x-ray diffraction | A | — | — |
| 5WCF | Human HMT1 hnrnp methyltransferase-like protein 6 (S. cerevisiae) | x-ray diffraction | A | A0S | — |
| 6P7I | Crystal structure of human PRMT6 in complex with S-adenosyl-L- homocysteine and YS17-117 compound | x-ray diffraction | A, B, C, D | O3P, O3S | — |
| 6W6D | Crystal structure of human protein arginine N-methyltransferase 6 (PRMT6) in complex with SGC6870… | x-ray diffraction | A | T9A | — |
| 6WAD | Crystal structure of human protein arginine N-methyltransferase 6 (PRMT6) in complex with MT2739… | x-ray diffraction | A | TQ7 | — |
| 7NR4 | X-ray structure of PRMT6 in complex with indazole type inhibitor | x-ray diffraction | A, B, C, D | UO2 | — |
| Q96LA8 | AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 6 (Q96LA8) | predicted | A | — | — |
Ligands
- 5NR · 2-[4-(phenylmethyl)piperidin-1-yl]ethanamine · in 1 record
- A0S · (5R)-4-(5-bromofuran-2-carbonyl)-5-(4-fluorophenyl)-7-methyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one · in 1 record
- O3P · N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]prop-2-enamide · in 1 record
- O3S · N-[3-(4-{[(2-aminoethyl)(methyl)amino]methyl}-1H-pyrrol-3-yl)phenyl]propanamide · in 1 record
- SAH · S-adenosyl-L-homocysteine · in 1 record
- T9A · (5R)-4-(5-bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one · in 1 record
- TQ7 · 5-bromo-N-(diphenylmethyl)-N-methylthiophene-2-carboxamide · in 1 record
- UNX · Unknown atom or ion · in 1 record
- UO2 · (2~{S})-2-azanyl-~{N}-[3-[3-(dimethylsulfamoyl)phenyl]-2~{H}-indazol-5-yl]propanamide · in 1 record
Experiment against prediction
- 5EGS chain A against the predicted model Q96LA8: TM-score 0.99, RMSD 0.46 Å
- 5EGS chain A against the predicted model Q96LA8: TM-score 0.99, RMSD 0.46 Å
- 7NR4 chain A against the predicted model Q96LA8: TM-score 0.99, RMSD 0.47 Å
- 4Y30 chain B against the predicted model Q96LA8: TM-score 0.99, RMSD 0.50 Å
- 4Y30 chain B against the predicted model Q96LA8: TM-score 0.99, RMSD 0.50 Å
- 5E8R chain A against the predicted model Q96LA8: TM-score 0.99, RMSD 0.46 Å
- 5E8R chain B against the predicted model Q96LA8: TM-score 0.99, RMSD 0.47 Å
- 5EGS chain B against the predicted model Q96LA8: TM-score 0.99, RMSD 0.62 Å
- 5EGS chain B against the predicted model Q96LA8: TM-score 0.99, RMSD 0.62 Å
- 4Y2H chain B against the predicted model Q96LA8: TM-score 0.99, RMSD 0.54 Å
Elsewhere
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