UniProt Q96L34
MAP/microtubule affinity-regulating kinase 4 (Q96L34)
MAP/microtubule affinity-regulating kinase 4 (UniProt Q96L34): 3 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q96L34
- Protein
- MAP/microtubule affinity-regulating kinase 4
- Experimental structures
- 3
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 8 · 1 record with a druggable one
Structures
4 records of Q96L34 in the MolNFT archive: 3 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5ES1 | Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a… | x-ray diffraction | A | 5RC | — |
| 5ES1 | Crystal structure of microtubule affinity-regulating kinase 4 catalytic domain in complex with a… | x-ray diffraction | A | — | — |
| 8XFL | The Crystal Structure of MARK4 from Biortus. | x-ray diffraction | A, B | — | 8 (best 0.67) |
| Q96L34 | AlphaFold monomer V2.0 prediction for MAP/MICROTUBULE affinity- regulating kinase 4 (Q96L34) | predicted | A | — | — |
Ligands
- 5RC · ~{N}-[(1~{R},6~{R})-6-azanyl-2,2-bis(fluoranyl)cyclohexyl]-5-ethyl-4-[6-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide · in 1 record
Experiment against prediction
- 5ES1 chain A against the predicted model Q96L34: TM-score 0.98, RMSD 0.93 Å
- 5ES1 chain A against the predicted model Q96L34: TM-score 0.98, RMSD 0.93 Å
- 8XFL chain B against the predicted model Q96L34: TM-score 0.95, RMSD 1.77 Å
- 8XFL chain A against the predicted model Q96L34: TM-score 0.94, RMSD 1.86 Å
Elsewhere
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