UniProt Q96IY4
Carboxypeptidase B2 (Q96IY4)
Carboxypeptidase B2 (UniProt Q96IY4), EC 3.4.17.20: 20 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96IY4
- Protein
- Carboxypeptidase B2
- EC
- 3.4.17.20
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 4 · 2 records with a druggable one
Structures
21 records of Q96IY4 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3D66 | Crystal structure of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) | x-ray diffraction | A, B, C | — | — |
| 3D66 | Crystal structure of thrombin-activatable fibrinolysis inhibitor (tafi) | x-ray diffraction | A, B, C | — | — |
| 3D67 | Crystal structure of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) in complex with… | x-ray diffraction | A, B, C | — | — |
| 3D67 | Crystal structure of thrombin-activatable fibrinolysis inhibitor (tafi) in complex with… | x-ray diffraction | A, B, C | — | — |
| 3D68 | Crystal structure of a T325I/T329I/H333Y/H335Q mutant of Thrombin-Activatable Fibrinolysis… | x-ray diffraction | A, B, C | — | — |
| 3D68 | Crystal structure of a T325I/T329I/H333Y/H335Q mutant of thrombin- activatable fibrinolysis… | x-ray diffraction | A, B, C | — | — |
| 3LMS | Structure of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa, in complex with… | x-ray diffraction | A | — | — |
| 3LMS | Structure of human activated thrombin-activatable fibrinolysis inhibitor, tafia, in complex with… | x-ray diffraction | A | — | — |
| 4P10 | pro-carboxypeptidase U In Complex With 5-(3-aminopropyl)-1-propyl-6,7-dihydro-4H-benzimidazole-5-car… | x-ray diffraction | A | — | — |
| 4P10 | Pro-carboxypeptidase U in complex with 5-(3-aminopropyl)-1-propyl-6,7… | x-ray diffraction | A | — | — |
| 5HVF | Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory… | x-ray diffraction | A | NAG, ZN | — |
| 5HVF | Crystal structure of thrombin-activatable fibrinolysis inhibitor in complex with an inhibitory… | x-ray diffraction | A | — | — |
| 5HVG | Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory… | x-ray diffraction | A, C | NAG, ZN | — |
| 5HVG | Crystal structure of thrombin-activatable fibrinolysis inhibitor in complex with an inhibitory… | x-ray diffraction | A, C | — | — |
| 5HVH | Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory… | x-ray diffraction | A | NAG, ZN | — |
| 5HVH | Crystal structure of thrombin-activatable fibrinolysis inhibitor in complex with two inhibitory… | x-ray diffraction | A | — | — |
| 7NEE | Inhibitor Complex with Thrombin Activatable Fibrinolysis inhibitor (TAFIa) | x-ray diffraction | A | U9B, ZN | 2 (best 0.73) |
| 7NEE | Inhibitor complex with thrombin activatable fibrinolysis inhibitor (tafia) | x-ray diffraction | A | U9B, ZN | — |
| 7NEU | Inhibitor Complex with Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) | x-ray diffraction | A | U9K, ZN, NA, CL, NAG | 2 (best 0.75) |
| 7NEU | Inhibitor complex with thrombin activatable fibrinolysis inhibitor (tafia) | x-ray diffraction | A | U9K, ZN, NA, CL, NAG | — |
| Q96IY4 | AlphaFold monomer V2.0 prediction for carboxypeptidase B2 (Q96IY4) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 7 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- CL · Chloride ion · in 2 records
- NA · Sodium ion · in 2 records
- U9B · (1R,3S)-3-(4-ammoniobutyl)-1-benzyl-1,4-azaphosphinan-1-ium-3-carboxylate 4,4-dioxide · in 2 records
- U9K · (1R,3S)-3-(4-ammoniobutyl)-1-(4-fluoro-2-(1-methyl-1H-imidazol-5-yl)benzyl)-1,4-azaphosphinan-1-ium-3-carboxylate 4,4-dioxide · in 2 records
Experiment against prediction
- 5HVG chain C against the predicted model Q96IY4: TM-score 1.00, RMSD 0.35 Å
- 5HVG chain C against the predicted model Q96IY4: TM-score 1.00, RMSD 0.35 Å
- 5HVF chain A against the predicted model Q96IY4: TM-score 1.00, RMSD 0.35 Å
- 5HVF chain A against the predicted model Q96IY4: TM-score 1.00, RMSD 0.35 Å
- 5HVG chain A against the predicted model Q96IY4: TM-score 1.00, RMSD 0.39 Å
- 5HVG chain A against the predicted model Q96IY4: TM-score 1.00, RMSD 0.39 Å
- 3D67 chain A against the predicted model Q96IY4: TM-score 0.99, RMSD 0.55 Å
- 3D67 chain A against the predicted model Q96IY4: TM-score 0.99, RMSD 0.55 Å
- 3D67 chain C against the predicted model Q96IY4: TM-score 0.99, RMSD 0.58 Å
- 3D67 chain C against the predicted model Q96IY4: TM-score 0.99, RMSD 0.58 Å
Elsewhere
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