UniProt Q96G25
Isoform 2 of Mediator of RNA polymerase II transcription subunit 8 (Q96G25)
Isoform 2 of Mediator of RNA polymerase II transcription subunit 8 (UniProt Q96G25): 9 experimental structures and 1 predicted model on GenesisL1, 5 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q96G25
- Protein
- Isoform 2 of Mediator of RNA polymerase II transcription subunit 8
- Experimental structures
- 9
- Predicted models
- 1
- Pockets
- 5 · 3 records with a druggable one
Structures
10 records of Q96G25 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EMF | Human Mediator (deletion of MED1-IDR) in a Tail-extended conformation | electron microscopy | H | — | 1 (best 0.74) |
| 7EMF | Human mediator (deletion of MED1-idr) in a tail-extended conformation | electron microscopy | H | — | — |
| 7ENA | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) | electron microscopy | h | — | — |
| 7ENC | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) | electron microscopy | h | — | — |
| 7ENJ | Human mediator (deletion of MED1-idr) in a tail-bent conformation (med-B) | electron microscopy | H | — | — |
| 7NVR | Human Mediator with RNA Polymerase II Pre-initiation complex | electron microscopy | b | — | — |
| 7NVR | Human mediator with RNA polymerase II pre-initiation complex | electron microscopy | b | — | — |
| 8GXQ | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state | electron microscopy | h | — | 2 (best 0.81) |
| 8TQW | Structure of human transcriptional Mediator complex | electron microscopy | H | — | 2 (best 0.83) |
| Q96G25 | AlphaFold monomer V2.0 prediction for mediator of RNA polymerase II transcription subunit 8 (Q96G25) | predicted | A | — | — |
Experiment against prediction
- 8GXQ chain h against the predicted model Q96G25: TM-score 0.79, RMSD 2.16 Å
- 7ENA chain h against the predicted model Q96G25: TM-score 0.78, RMSD 2.06 Å
- 7EMF chain H against the predicted model Q96G25: TM-score 0.78, RMSD 1.71 Å
- 7EMF chain H against the predicted model Q96G25: TM-score 0.78, RMSD 1.71 Å
- 7ENJ chain H against the predicted model Q96G25: TM-score 0.78, RMSD 1.71 Å
- 7NVR chain b against the predicted model Q96G25: TM-score 0.77, RMSD 1.40 Å
- 7NVR chain b against the predicted model Q96G25: TM-score 0.77, RMSD 1.40 Å
- 7ENC chain h against the predicted model Q96G25: TM-score 0.77, RMSD 2.09 Å
- 8TQW chain H against the predicted model Q96G25: TM-score 0.74, RMSD 2.78 Å
Elsewhere
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