UniProt Q96EB6
NAD-dependent protein deacetylase sirtuin-1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (UniProt Q96EB6), EC 3.5.1.-: 16 experimental structures on GenesisL1, 3 ligands bound, 3 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q96EB6
- Protein
- NAD-dependent protein deacetylase sirtuin-1
- EC
- 3.5.1.-
- Experimental structures
- 16
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 3 · 1 record with a druggable one
Structures
16 records of Q96EB6 in the MolNFT archive: 16 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4I5I | Crystal structure of the SIRT1 catalytic domain bound to NAD and an EX527 analog | x-ray diffraction | A, B | — | — |
| 4I5I | Crystal structure of the SIRT1 catalytic domain bound to NAD and an EX527 analog | x-ray diffraction | A, B | — | — |
| 4IF6 | Structure of NAD-dependent protein deacetylase sirtuin-1 (closed state, 2.25 A) | x-ray diffraction | A, B | — | — |
| 4IF6 | Structure of NAD-dependent protein deacetylase sirtuin-1 (closed state, 2.25 a) | x-ray diffraction | A, B | — | — |
| 4IG9 | Structure of NAD-dependent protein deacetylase sirtuin-1 (open state, 2.64 A) | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4IG9 | Structure of NAD-dependent protein deacetylase sirtuin-1 (open state, 2.64 a) | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4KXQ | Structure of NAD-dependent protein deacetylase sirtuin-1 (closed state, 1.85 A) | x-ray diffraction | A, B | — | — |
| 4KXQ | Structure of NAD-dependent protein deacetylase sirtuin-1 (closed state, 1.85 a) | x-ray diffraction | A, B | — | — |
| 4ZZH | SIRT1/Activator Complex | x-ray diffraction | A | — | — |
| 4ZZH | SIRT1/ACTIVATOR complex | x-ray diffraction | A | — | — |
| 4ZZI | SIRT1/Activator/Inhibitor Complex | x-ray diffraction | A | — | — |
| 4ZZI | SIRT1/ACTIVATOR/INHIBITOR complex | x-ray diffraction | A | — | — |
| 4ZZJ | SIRT1/Activator/Substrate Complex | x-ray diffraction | A | ZN, CNA, 4TQ | 3 (best 0.80) |
| 4ZZJ | SIRT1/ACTIVATOR/SUBSTRATE complex | x-ray diffraction | A | — | — |
| 5BTR | Crystal structure of SIRT1 in complex with resveratrol and an amc- containing peptide | x-ray diffraction | A, B, C | — | — |
| Q96EB6 | AlphaFold monomer V2.0 prediction for NAD-dependent protein deacetylase sirtuin-1 (Q96EB6) | — | — | — |
Ligands
Elsewhere
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