UniProt Q96CB9
5-methylcytosine rRNA methyltransferase NSUN4 (Q96CB9)
5-methylcytosine rRNA methyltransferase NSUN4 (UniProt Q96CB9), EC 2.1.1.-: 18 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 54 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q96CB9
- Protein
- 5-methylcytosine rRNA methyltransferase NSUN4
- EC
- 2.1.1.-
- Experimental structures
- 18
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 54 · 9 records with a druggable one
Structures
19 records of Q96CB9 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4FP9 | Human MTERF4-NSUN4 protein complex | x-ray diffraction | A, C, D, F | SAM, SO4 | 18 (best 0.74) |
| 4FP9 | Human MTERF4-NSUN4 protein complex | x-ray diffraction | A, C, D, F | SAM, SO4 | 18 (best 0.74) |
| 4FZV | Crystal structure of the human MTERF4:NSUN4:SAM ternary complex | x-ray diffraction | A | SAM | 5 (best 0.67) |
| 4FZV | Crystal structure of the human MTERF4:NSUN4:SAM ternary complex | x-ray diffraction | A | SAM | 5 (best 0.67) |
| 7O9K | Human mitochondrial ribosome large subunit assembly intermediate with MTERF4-NSUN4, MRM2, MTG1, the… | electron microscopy | A1 | SAM | 1 (best 0.83) |
| 7O9M | Human mitochondrial ribosome large subunit assembly intermediate with MTERF4-NSUN4, MRM2, MTG1 and… | electron microscopy | A1 | SAM | — |
| 7ODR | State A of the human mitoribosomal large subunit assembly intermediate | electron microscopy | x | SAM | — |
| 7ODS | State B of the human mitoribosomal large subunit assembly intermediate | electron microscopy | x | SAM | — |
| 7ODT | State C of the human mitoribosomal large subunit assembly intermediate | electron microscopy | x | SAM | 1 (best 0.85) |
| 7OF0 | Structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with… | electron microscopy | C | — | — |
| 7OF0 | Structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with… | electron microscopy | C | — | — |
| 7OF3 | Structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with… | electron microscopy | C | — | — |
| 7OF5 | Structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with… | electron microscopy | C | — | 1 (best 0.83) |
| 7OF7 | Structure of a human mitochondrial ribosome large subunit assembly intermediate in complex with… | electron microscopy | C | — | 1 (best 0.83) |
| 7OIC | Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 4 | electron microscopy | x | SAM | — |
| 7PD3 | Structure of the human mitoribosomal large subunit in complex with NSUN4.MTERF4.GTPBP7 and… | electron microscopy | x | SAM | — |
| 8PK0 | human mitoribosomal large subunit assembly intermediate 1 with GTPBP10-GTPBP7 | electron microscopy | x | SAM | — |
| 8QSJ | Human mitoribosomal large subunit assembly intermediate 2 with GTPBP7 | electron microscopy | x | SAM | — |
| Q96CB9 | AlphaFold monomer V2.0 prediction for 5-methylcytosine rRNA methyltransferase NSUN4 (Q96CB9) | predicted | A | — | 4 (best 0.68) |
Ligands
Experiment against prediction
- 4FZV chain A against the predicted model Q96CB9: TM-score 1.00, RMSD 0.22 Å
- 4FZV chain A against the predicted model Q96CB9: TM-score 1.00, RMSD 0.22 Å
- 4FP9 chain F against the predicted model Q96CB9: TM-score 1.00, RMSD 0.45 Å
- 4FP9 chain F against the predicted model Q96CB9: TM-score 1.00, RMSD 0.45 Å
- 4FP9 chain C against the predicted model Q96CB9: TM-score 1.00, RMSD 0.46 Å
- 4FP9 chain C against the predicted model Q96CB9: TM-score 1.00, RMSD 0.46 Å
- 4FP9 chain A against the predicted model Q96CB9: TM-score 0.99, RMSD 0.50 Å
- 4FP9 chain A against the predicted model Q96CB9: TM-score 0.99, RMSD 0.50 Å
- 4FP9 chain D against the predicted model Q96CB9: TM-score 0.99, RMSD 0.60 Å
- 4FP9 chain D against the predicted model Q96CB9: TM-score 0.99, RMSD 0.60 Å
Elsewhere
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