UniProt Q96C86
M7GPPPX diphosphatase (Q96C86)
M7GPPPX diphosphatase (UniProt Q96C86), EC 3.6.1.59: 17 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q96C86
- Protein
- M7GPPPX diphosphatase
- EC
- 3.6.1.59
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 5 · 1 record with a druggable one
Structures
18 records of Q96C86 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ST0 | Structure of DcpS bound to m7GpppG | x-ray diffraction | B, A | — | — |
| 1ST0 | Structure of dcps bound to M7GPPPG | x-ray diffraction | B, A | — | — |
| 1ST4 | Structure of DcpS bound to m7GpppA | x-ray diffraction | B, A | — | — |
| 1ST4 | Structure of dcps bound to M7GPPPA | x-ray diffraction | B, A | — | — |
| 3BL7 | Synthetic Gene Encoded DcpS bound to inhibitor DG156844 | x-ray diffraction | A, B | — | — |
| 3BL7 | Synthetic gene encoded dcps bound to inhibitor DG156844 | x-ray diffraction | A, B | — | — |
| 3BL9 | Synthetic Gene Encoded DcpS bound to inhibitor DG157493 | x-ray diffraction | A, B | — | — |
| 3BL9 | Synthetic gene encoded dcps bound to inhibitor DG157493 | x-ray diffraction | A, B | — | — |
| 3BLA | Synthetic Gene Encoded DcpS bound to inhibitor DG153249 | x-ray diffraction | A, B | — | — |
| 3BLA | Synthetic gene encoded dcps bound to inhibitor DG153249 | x-ray diffraction | A, B | — | — |
| 4QDE | Dcps in complex with covalent inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4QDE | Dcps in complex with covalent inhibitor | x-ray diffraction | A, B, C, D | — | — |
| 4QDV | Dcps in complex with covalent ligand | x-ray diffraction | A, B, C, D | — | — |
| 4QDV | Dcps in complex with covalent ligand | x-ray diffraction | A, B, C, D | — | — |
| 4QEB | Dcps in complex with covalent inhibitor targeting Tyrosine | x-ray diffraction | A, B, C, D | — | — |
| 4QEB | Dcps in complex with covalent inhibitor targeting tyrosine | x-ray diffraction | A, B, C, D | — | — |
| 5OSY | Human decapping scavenger enzyme (hdcps) in complex with M7G(5'S) PPSP(5'S)G mRNA 5' cap analog | x-ray diffraction | A, B | AJQ | 5 (best 0.85) |
| Q96C86 | AlphaFold monomer V2.0 prediction for M7GPPPX diphosphatase (Q96C86) | predicted | A | — | — |
Ligands
- AJQ · [(2~{S},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-[[[(2~{S}, 3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl-oxidanyl-phosphoryl]oxy-sulfanyl-phosphoryl]oxy-phosphinic acid · in 1 record
Experiment against prediction
- 3BL7 chain A against the predicted model Q96C86: TM-score 0.82, RMSD 3.44 Å
- 3BL7 chain A against the predicted model Q96C86: TM-score 0.82, RMSD 3.44 Å
- 3BL9 chain A against the predicted model Q96C86: TM-score 0.82, RMSD 3.45 Å
- 3BL9 chain A against the predicted model Q96C86: TM-score 0.82, RMSD 3.45 Å
- 4QDV chain D against the predicted model Q96C86: TM-score 0.82, RMSD 3.53 Å
- 4QDV chain D against the predicted model Q96C86: TM-score 0.82, RMSD 3.53 Å
- 3BLA chain A against the predicted model Q96C86: TM-score 0.81, RMSD 3.53 Å
- 3BLA chain A against the predicted model Q96C86: TM-score 0.81, RMSD 3.53 Å
- 4QEB chain A against the predicted model Q96C86: TM-score 0.81, RMSD 3.53 Å
- 4QEB chain A against the predicted model Q96C86: TM-score 0.81, RMSD 3.53 Å
Elsewhere
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