UniProt Q94702

Intron-encoded endonuclease I-PpoI (Q94702)

Intron-encoded endonuclease I-PpoI (UniProt Q94702), EC 3.1.-.-: 58 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 329 pockets. Binding sites, druggability and experiment against prediction…

UniProt: Q94702
Protein: Intron-encoded endonuclease I-PpoI
EC: 3.1.-.-
Experimental structures: 58
Predicted models: 1
Ligands: 7
Pockets: 329 · 58 records with a druggable one

Structures

59 records of Q94702 in the MolNFT archive: 58 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
1A73	Intron-encoded endonuclease I-ppoi complexed with DNA	x-ray diffraction	A, B	MG, ZN	6 (best 0.64)
1A73	Intron-encoded endonuclease I-ppoi complexed with DNA	x-ray diffraction	A, B	MG, ZN	6 (best 0.64)
1A74	I-ppol homing ENDONUCLEASE/DNA complex	x-ray diffraction	A, B	ZN	5 (best 0.63)
1A74	I-ppol homing ENDONUCLEASE/DNA complex	x-ray diffraction	A, B	ZN	5 (best 0.63)
1CYQ	Intron encoded homing endonuclease I-ppoi (H98A)/DNA homing site complex	x-ray diffraction	A, B	MG, ZN	6 (best 0.64)
1CYQ	Intron encoded homing endonuclease I-ppoi (H98A)/DNA homing site complex	x-ray diffraction	A, B	MG, ZN	6 (best 0.64)
1CZ0	Intron encoded homing endonuclease I-PPOI/DNA complex lacking catalytic metal ion	x-ray diffraction	A, B	NA, ZN	6 (best 0.64)
1CZ0	Intron encoded homing endonuclease I-PPOI/DNA complex lacking catalytic metal ion	x-ray diffraction	A, B	NA, ZN	6 (best 0.64)
1EVW	L116A mutant of the homing endonuclease I-ppoi complexed to homing site DNA.	x-ray diffraction	A, B, C, D	MG, ZN	10 (best 0.72)
1EVW	L116A mutant of the homing endonuclease I-ppoi complexed to homing site DNA.	x-ray diffraction	A, B, C, D	MG, ZN	10 (best 0.72)
1EVX	Apo crystal structure of the homing endonuclease, I-ppoi	x-ray diffraction	A, B	ZN, SO4	3 (best 0.64)
1EVX	Apo crystal structure of the homing endonuclease, I-ppoi	x-ray diffraction	A, B	ZN, SO4	3 (best 0.64)
1IPP	Homing ENDONUCLEASE/DNA complex	x-ray diffraction	A, B	CD, MG	6 (best 0.64)
1IPP	Homing ENDONUCLEASE/DNA complex	x-ray diffraction	A, B	CD, MG	6 (best 0.64)
2O6M	H98Q mutant of the homing endonuclease I-PPOI complexed with DNA	x-ray diffraction	A, B	MG, ZN	6 (best 0.62)
2O6M	H98Q mutant of the homing endonuclease I-ppoi complexed with DNA	x-ray diffraction	A, B	MG, ZN	6 (best 0.62)
8VMO	Homing endonuclease I-PpoI-DNA complex:ground state at pH7.0 (K+ MES) with Na+	x-ray diffraction	A, B	NA, ZN	6 (best 0.63)
8VMP	Homing endonuclease I-PpoI-DNA complex:reaction at pH7.0 (K+ MES) with 500 uM Mg2+ for 10s	x-ray diffraction	A, B	NA, ZN	5 (best 0.64)
8VMQ	Homing endonuclease I-PpoI-DNA complex:reaction at pH7.0 (K+ MES) with 500 uM Mg2+ for 20s	x-ray diffraction	A, B	MG, NA, ZN	6 (best 0.63)
8VMR	Homing endonuclease I-PpoI-DNA complex:reaction at pH7.0 (K+ MES) with 500 uM Mg2+ for 40s	x-ray diffraction	A, B	MG, NA, ZN	6 (best 0.64)
8VMS	Homing endonuclease I-PpoI-DNA complex:reaction at pH7.0 (K+ MES) with 500 uM Mg2+ for 80s	x-ray diffraction	A, B	MG, NA, ZN	5 (best 0.64)
8VMT	Homing endonuclease I-PpoI-DNA complex:reaction at pH7.0 (K+ MES) with 500 uM Mg2+ for 160s	x-ray diffraction	A, B	MG, NA, ZN	6 (best 0.64)
8VMU	Homing endonuclease I-PpoI-DNA complex:reaction at pH7.0 (K+ MES) with 500 uM Mg2+ for 320s	x-ray diffraction	A, B	MG, NA, ZN	6 (best 0.64)
8VMV	Homing endonuclease I-PpoI-DNA complex:reaction at pH7.0 (K+ MES) with 500 uM Mg2+ for 600s	x-ray diffraction	A, B	MG, NA, ZN	5 (best 0.64)
8VMW	Homing endonuclease I-PpoI-DNA complex:ground state at pH6.0 (K+ MES) with Na+	x-ray diffraction	A, B	NA, ZN	6 (best 0.62)
8VMX	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mg2+ for 10s	x-ray diffraction	A, B	NA, ZN	5 (best 0.64)
8VMY	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mg2+ for 20s	x-ray diffraction	A, B	NA, MG, ZN	6 (best 0.63)
8VMZ	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mg2+ for 40s	x-ray diffraction	A, B	MG, NA, ZN	6 (best 0.65)
8VN0	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mg2+ for 80s	x-ray diffraction	A, B	MG, NA, ZN	6 (best 0.63)
8VN1	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mg2+ for 160s	x-ray diffraction	A, B	MG, NA, ZN	6 (best 0.64)
8VN2	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mg2+ for 320s	x-ray diffraction	A, B	MG, NA, ZN	6 (best 0.64)
8VN3	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mg2+ for 600s	x-ray diffraction	A, B	MG, NA, ZN	5 (best 0.64)
8VN4	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mg2+ for 1200s	x-ray diffraction	A, B	MG, NA, ZN	5 (best 0.63)
8VN5	Homing endonuclease I-PpoI-DNA complex:ground state at pH8.0 (Tris) with Na+	x-ray diffraction	A, B	NA, ZN	6 (best 0.63)
8VN6	Homing endonuclease I-PpoI-DNA complex:reaction at pH8.0 (Tris) with 500 uM Mg2+ for 10s	x-ray diffraction	A, B	MG, NA, ZN	6 (best 0.64)
8VN7	Homing endonuclease I-PpoI-DNA complex:reaction at pH8.0 (Tris) with 500 uM Mg2+ for 20s	x-ray diffraction	A, B	MG, NA, ZN	6 (best 0.64)
8VN8	Homing endonuclease I-PpoI-DNA complex:reaction at pH8.0 (Tris) with 500 uM Mg2+ for 40s	x-ray diffraction	A, B	MG, NA, ZN	6 (best 0.64)
8VN9	Homing endonuclease I-PpoI-DNA complex:reaction at pH8.0 (Tris) with 500 uM Mg2+ for 80s	x-ray diffraction	A, B	MG, NA, ZN	5 (best 0.64)
8VNA	Homing endonuclease I-PpoI-DNA complex:reaction at pH8.0 (Tris) with 500 uM Mg2+ for 160s	x-ray diffraction	A, B	MG, NA, ZN	5 (best 0.64)
8VNB	Homing endonuclease I-PpoI-DNA complex:reaction at pH8.0 (Tris) with 500 uM Mg2+ for 240s	x-ray diffraction	A, B	ZN, MG	6 (best 0.64)
8VNC	Homing endonuclease I-PpoI-DNA complex:reaction at pH8.0 (Tris) with 500 uM Mg2+ for 320s	x-ray diffraction	A, B	ZN, MG	6 (best 0.65)
8VND	Homing endonuclease I-PpoI-DNA complex:reaction at pH8.0 (Tris) with 500 uM Mg2+ for 600s	x-ray diffraction	A, B	ZN, MG	5 (best 0.63)
8VNE	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mn2+ for 10s	x-ray diffraction	A, B	MN, NA, ZN	6 (best 0.64)
8VNF	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mn2+ for 20s	x-ray diffraction	A, B	MN, NA, ZN	6 (best 0.65)
8VNG	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mn2+ for 40s	x-ray diffraction	A, B	MN, NA, ZN	5 (best 0.64)
8VNH	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mn2+ for 80s	x-ray diffraction	A, B	MN, NA, ZN	6 (best 0.65)
8VNJ	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mn2+ for 120s	x-ray diffraction	A, B	MN, NA, ZN	6 (best 0.64)
8VNK	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mn2+ for 160s	x-ray diffraction	A, B	MN, NA, ZN	6 (best 0.65)
8VNL	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mn2+ for 240s	x-ray diffraction	A, B	MN, NA, ZN	5 (best 0.64)
8VNM	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mn2+ for 320s	x-ray diffraction	A, B	MN, NA, ZN	4 (best 0.64)
8VNN	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mn2+ for 480s	x-ray diffraction	A, B	MN, NA, ZN	5 (best 0.64)
8VNO	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mn2+ for 600s	x-ray diffraction	A, B	MN, NA, ZN	5 (best 0.62)
8VNP	Homing endonuclease I-PpoI-DNA complex at pH6.0 (K+ MES) with 0.2 M sodium malonate	x-ray diffraction	A, B	NA, ZN	5 (best 0.62)
8VNQ	Homing endonuclease H98A I-PpoI-DNA complex at pH6.0 (K+ MES) with 1 mM Mn2+ for 1800s	x-ray diffraction	A, B	NA, ZN	6 (best 0.66)
8VNR	Homing endonuclease H98A I-PpoI-DNA complex at pH6.0 (K+ MES) with 1 mM Mn2+ for 600s and then 100…	x-ray diffraction	A, B	NA, ZN	5 (best 0.65)
8VNS	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 200 mM Mn2+ for 600s	x-ray diffraction	A, B	MN, NA, ZN	4 (best 0.66)
8VNT	Homing endonuclease I-PpoI-DNA complex:reaction at pH6.0 (K+ MES) with 500 uM Mg2+ for 1800s	x-ray diffraction	A, B	ZN, MG	5 (best 0.66)
8VNU	Homing endonuclease H98A I-PpoI-DNA complex at pH6.0 (K+ MES) with 70 mM Tl+ for 1800s	x-ray diffraction	A, B	TL, NA, ZN	6 (best 0.64)
Q94702	AlphaFold monomer V2.0 prediction for intron-encoded endonuclease I-ppoi (Q94702)	predicted	A	—	1 (best 0.36)

Ligands

ZN · Zinc ion · in 56 records
NA · Sodium ion · in 40 records
MG · Magnesium ion · in 32 records
MN · Manganese (II) ion · in 11 records
CD · Cadmium ion · in 2 records
SO4 · Sulfate ion · in 2 records
TL · Thallium (I) ion · in 1 record

Experiment against prediction

8VNT chain B against the predicted model Q94702: TM-score 0.99, RMSD 0.55 Å
8VNO chain B against the predicted model Q94702: TM-score 0.99, RMSD 0.57 Å
8VN1 chain B against the predicted model Q94702: TM-score 0.99, RMSD 0.56 Å
8VN8 chain B against the predicted model Q94702: TM-score 0.99, RMSD 0.56 Å
8VN2 chain B against the predicted model Q94702: TM-score 0.99, RMSD 0.57 Å
8VNK chain B against the predicted model Q94702: TM-score 0.99, RMSD 0.57 Å
8VMZ chain B against the predicted model Q94702: TM-score 0.99, RMSD 0.57 Å
8VMQ chain B against the predicted model Q94702: TM-score 0.99, RMSD 0.57 Å
8VMX chain B against the predicted model Q94702: TM-score 0.99, RMSD 0.57 Å
8VNS chain A against the predicted model Q94702: TM-score 0.99, RMSD 0.57 Å

Elsewhere

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.