UniProt Q92731
Estrogen receptor beta (Q92731)
Estrogen receptor beta (UniProt Q92731): 70 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 38 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q92731
- Protein
- Estrogen receptor beta
- Experimental structures
- 70
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 38 · 6 records with a druggable one
Structures
71 records of Q92731 in the MolNFT archive: 70 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1L2J | Human Estrogen Receptor beta Ligand-binding Domain in Complex with… | x-ray diffraction | A, B | — | — |
| 1L2J | Human estrogen receptor beta ligand-binding domain in complex with (R… | x-ray diffraction | A, B | — | — |
| 1NDE | Estrogen Receptor beta with Selective Triazine Modulator | x-ray diffraction | A | — | — |
| 1NDE | Estrogen receptor beta with selective triazine modulator | x-ray diffraction | A | — | — |
| 1QKM | Human oestrogen receptor beta ligand-binding domain in complex with partial agonist genistein | x-ray diffraction | A | — | — |
| 1QKM | Human oestrogen receptor beta ligand-binding domain in complex with partial agonist genistein | x-ray diffraction | A | — | — |
| 1U3Q | Crystal Structure of Estrogen Receptor beta complexed with CL-272 | x-ray diffraction | A, B, C, D | — | — |
| 1U3Q | Crystal structure of estrogen receptor beta complexed with cl-272 | x-ray diffraction | A, B, C, D | — | — |
| 1U3R | Crystal Structure of Estrogen Receptor beta complexed with WAY-338 | x-ray diffraction | A, B | — | — |
| 1U3R | Crystal structure of estrogen receptor beta complexed with way-338 | x-ray diffraction | A, B | — | — |
| 1U3S | Crystal Structure of Estrogen Receptor beta complexed with WAY-797 | x-ray diffraction | A, B | — | — |
| 1U3S | Crystal structure of estrogen receptor beta complexed with way-797 | x-ray diffraction | A, B | — | — |
| 1U9E | Crystal structure of estrogen receptor beta complexed with way-397 | x-ray diffraction | A, B | — | — |
| 1U9E | Crystal structure of estrogen receptor beta complexed with way-397 | x-ray diffraction | A, B | — | — |
| 1X76 | Crystal structure of estrogen receptor beta complexed with way-697 | x-ray diffraction | A, B | — | — |
| 1X76 | Crystal structure of estrogen receptor beta complexed with way-697 | x-ray diffraction | A, B | — | — |
| 1X78 | Crystal structure of estrogen receptor beta complexed with way-244 | x-ray diffraction | A, B | — | — |
| 1X78 | Crystal structure of estrogen receptor beta complexed with way-244 | x-ray diffraction | A, B | — | — |
| 1X7B | Crystal structure of estrogen receptor beta complexed with erb-041 | x-ray diffraction | A, B | — | — |
| 1X7B | Crystal structure of estrogen receptor beta complexed with erb-041 | x-ray diffraction | A, B | — | — |
| 1X7J | Crystal structure of estrogen receptor beta complexed with genistein | x-ray diffraction | A, B | — | — |
| 1X7J | Crystal structure of estrogen receptor beta complexed with genistein | x-ray diffraction | A, B | — | — |
| 1ZAF | Crystal structure of estrogen receptor beta complexed with… | x-ray diffraction | A, B | — | — |
| 1ZAF | Crystal structure of estrogen receptor beta complexed with… | x-ray diffraction | A, B | — | — |
| 2FSZ | A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen… | x-ray diffraction | A, B | — | — |
| 2FSZ | A second binding site for hydroxytamoxifen within the coactivator- binding groove of estrogen… | x-ray diffraction | A, B | — | — |
| 2GIU | Human estrogen receptor beta ligand-binding domain in complex with compound 45 | x-ray diffraction | A | — | — |
| 2GIU | Human estrogen receptor beta ligand-binding domain in complex with compound 45 | x-ray diffraction | A | — | — |
| 2I0G | Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of… | x-ray diffraction | A, B | — | — |
| 2I0G | Benzopyrans are selective estrogen receptor beta agonists (serbas) with novel activity in models of… | x-ray diffraction | A, B | — | — |
| 2JJ3 | Estrogen receptor beta ligand binding domain in complex with a Benzopyran agonist | x-ray diffraction | A, B | — | — |
| 2JJ3 | Estrogen receptor beta ligand binding domain in complex with a benzopyran agonist | x-ray diffraction | A, B | — | — |
| 2NV7 | Crystal Structure of Estrogen Receptor Beta Complexed with WAY-555 | x-ray diffraction | A, B | — | — |
| 2NV7 | Crystal structure of estrogen receptor beta complexed with way-555 | x-ray diffraction | A, B | — | — |
| 2QTU | Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand | x-ray diffraction | A, B | — | — |
| 2QTU | Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand | x-ray diffraction | A, B | — | — |
| 2YJD | Stapled peptide bound to Estrogen Receptor Beta | x-ray diffraction | A, B | — | — |
| 2YJD | Stapled peptide bound to estrogen receptor beta | x-ray diffraction | A, B | — | — |
| 2YLY | Sulfonamides as selective Estrogen Receptor beta Agonists. | x-ray diffraction | A, B | — | — |
| 2YLY | Sulfonamides as selective estrogen receptor beta agonists. | x-ray diffraction | A, B | — | — |
| 2Z4B | Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand | x-ray diffraction | A, B | — | — |
| 2Z4B | Estrogen receptor beta ligand-binding domain complexed to a benzopyran ligand | x-ray diffraction | A, B | — | — |
| 3OLL | Crystal structure of phosphorylated estrogen receptor beta ligand binding domain | x-ray diffraction | A, B | — | — |
| 3OLL | Crystal structure of phosphorylated estrogen receptor beta ligand binding domain | x-ray diffraction | A, B | — | — |
| 3OLS | Crystal structure of estrogen receptor beta ligand binding domain | x-ray diffraction | A, B | — | — |
| 3OLS | Crystal structure of estrogen receptor beta ligand binding domain | x-ray diffraction | A, B | — | — |
| 3OMO | Fragment-Based Design of novel Estrogen Receptor Ligands | x-ray diffraction | A, B | — | — |
| 3OMO | Fragment-based design of novel estrogen receptor ligands | x-ray diffraction | A, B | — | — |
| 3OMP | Fragment-Based Design of novel Estrogen Receptor Ligands | x-ray diffraction | A, B | — | — |
| 3OMP | Fragment-based design of novel estrogen receptor ligands | x-ray diffraction | A, B | — | — |
| 3OMQ | Fragment-Based Design of novel Estrogen Receptor Ligands | x-ray diffraction | A, B | — | — |
| 3OMQ | Fragment-based design of novel estrogen receptor ligands | x-ray diffraction | A, B | — | — |
| 4J24 | Estrogen Receptor in complex with proline-flanked LXXLL peptides | x-ray diffraction | A, B, C, D | — | — |
| 4J24 | Estrogen receptor in complex with proline-flanked lxxll peptides | x-ray diffraction | A, B, C, D | — | — |
| 4J26 | Estrogen Receptor in complex with proline-flanked LXXLL peptides | x-ray diffraction | A, B | — | — |
| 4J26 | Estrogen receptor in complex with proline-flanked lxxll peptides | x-ray diffraction | A, B | — | — |
| 4ZI1 | Human estrogen receptor beta ligand-binding domain in complex with KB095285 and CIA12 coactivator… | x-ray diffraction | A | — | — |
| 4ZI1 | Human estrogen receptor beta ligand-binding domain in complex with KB095285 and CIA12 coactivator… | x-ray diffraction | A | — | — |
| 5TOA | Crystal Structure of ER beta bound to Estradiol | x-ray diffraction | A, B | EST | 7 (best 0.83) |
| 5TOA | Crystal structure of er beta bound to estradiol | x-ray diffraction | A, B | EST | — |
11 records more on the page itself.
Ligands
- EST · Estradiol · in 2 records
- I0K · (2~{S})-2,3-bis(4-hydroxyphenyl)propanenitrile · in 2 records
- I1D · (2~{R})-3-(2-chloranyl-4-oxidanyl-phenyl)-2-(4-hydroxyphenyl)propanenitrile · in 2 records
- I1I · (2~{S})-3-(2-chloranyl-4-oxidanyl-phenyl)-2-(4-hydroxyphenyl)propanenitrile · in 2 records
- I1M · (2~{R})-2-(2-chloranyl-4-oxidanyl-phenyl)-3-(4-hydroxyphenyl)propanenitrile · in 2 records
- I2B · (2~{S})-2-(2-chloranyl-4-oxidanyl-phenyl)-3-(4-hydroxyphenyl)propanenitrile · in 2 records
Experiment against prediction
- 1U3S chain B against the predicted model Q92731: TM-score 0.99, RMSD 0.66 Å
- 1U3S chain B against the predicted model Q92731: TM-score 0.99, RMSD 0.66 Å
- 7XVZ chain B against the predicted model Q92731: TM-score 0.99, RMSD 0.69 Å
- 7XVZ chain B against the predicted model Q92731: TM-score 0.99, RMSD 0.69 Å
- 1X7J chain B against the predicted model Q92731: TM-score 0.99, RMSD 0.71 Å
- 1X7J chain B against the predicted model Q92731: TM-score 0.99, RMSD 0.71 Å
- 7XWP chain B against the predicted model Q92731: TM-score 0.99, RMSD 0.69 Å
- 7XWP chain B against the predicted model Q92731: TM-score 0.99, RMSD 0.69 Å
- 7XWR chain B against the predicted model Q92731: TM-score 0.99, RMSD 0.70 Å
- 7XWR chain B against the predicted model Q92731: TM-score 0.99, RMSD 0.70 Å
Elsewhere
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