UniProt Q8ZQ06
Beta-hexosaminidase (Q8ZQ06)
Beta-hexosaminidase (UniProt Q8ZQ06), EC 3.2.1.52: 10 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 45 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8ZQ06
- Protein
- Beta-hexosaminidase
- EC
- 3.2.1.52
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 45 · 11 records with a druggable one
Structures
11 records of Q8ZQ06 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4GVF | Crystal structure of Salmonella typhimurium family 3 glycoside hydrolase (NagZ) bound to GlcNAc | x-ray diffraction | A, B | NDG, NAG | 5 (best 0.71) |
| 4GVF | Crystal structure of salmonella typhimurium family 3 glycoside hydrolase (nagz) bound to glcnac | x-ray diffraction | A, B | NDG, NAG | 5 (best 0.71) |
| 4GVG | Crystal structure of Salmonella typhimurium family 3 glycoside hydrolase (NagZ) | x-ray diffraction | A, B | — | 3 (best 0.66) |
| 4GVG | Crystal structure of salmonella typhimurium family 3 glycoside hydrolase (nagz) | x-ray diffraction | A, B | — | 3 (best 0.66) |
| 4GVH | Crystal structure of Salmonella typhimurium family 3 glycoside hydrolase (NagZ) covalently bound to… | x-ray diffraction | A, B | 0XY | 5 (best 0.68) |
| 4GVH | Crystal structure of salmonella typhimurium family 3 glycoside hydrolase (nagz) covalently bound to… | x-ray diffraction | A, B | 0XY | 5 (best 0.68) |
| 4GVI | Crystal structure of mutant (D248N) Salmonella typhimurium family 3 glycoside hydrolase (NagZ) in… | x-ray diffraction | A, B | NAG, AH0 | 5 (best 0.66) |
| 4GVI | Crystal structure of mutant (D248N) salmonella typhimurium family 3 glycoside hydrolase (nagz) in… | x-ray diffraction | A, B | NAG, AH0 | 5 (best 0.66) |
| 4HZM | Crystal structure of Salmonella typhimurium family 3 glycoside hydrolase (NagZ) bound to… | x-ray diffraction | A, B | 1BW | 4 (best 0.69) |
| 4HZM | Crystal structure of salmonella typhimurium family 3 glycoside hydrolase (nagz) bound to… | x-ray diffraction | A, B | 1BW | 4 (best 0.69) |
| Q8ZQ06 | AlphaFold monomer V2.0 prediction for beta-hexosaminidase (Q8ZQ06) | predicted | A | — | 1 (best 0.57) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 4 records
- 0XY · 5-fluoro-N-acetyl-alpha-D-glucosamine · in 2 records
- 1BW · N-[(3S,4R,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)piperidin-3-yl]butanamide · in 2 records
- AH0 · 2-(2-acetylamino-4-hydroxy-6,8-dioxa-bicyclo[3.2.1]oct-3-yloxy)-propionic acid · in 2 records
- NDG · 2-acetamido-2-deoxy-alpha-D-glucopyranose · in 2 records
Experiment against prediction
- 4GVH chain B against the predicted model Q8ZQ06: TM-score 0.99, RMSD 0.63 Å
- 4GVH chain B against the predicted model Q8ZQ06: TM-score 0.99, RMSD 0.63 Å
- 4GVF chain B against the predicted model Q8ZQ06: TM-score 0.99, RMSD 0.65 Å
- 4GVF chain B against the predicted model Q8ZQ06: TM-score 0.99, RMSD 0.65 Å
- 4GVG chain A against the predicted model Q8ZQ06: TM-score 0.99, RMSD 0.67 Å
- 4GVG chain A against the predicted model Q8ZQ06: TM-score 0.99, RMSD 0.67 Å
- 4GVG chain B against the predicted model Q8ZQ06: TM-score 0.99, RMSD 0.70 Å
- 4GVG chain B against the predicted model Q8ZQ06: TM-score 0.99, RMSD 0.70 Å
- 4HZM chain A against the predicted model Q8ZQ06: TM-score 0.99, RMSD 0.70 Å
- 4HZM chain A against the predicted model Q8ZQ06: TM-score 0.99, RMSD 0.70 Å
Elsewhere
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