UniProt Q8WW01
tRNA-splicing endonuclease subunit Sen15 (Q8WW01)
tRNA-splicing endonuclease subunit Sen15 (UniProt Q8WW01): 7 experimental structures and 1 predicted model on GenesisL1, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8WW01
- Protein
- tRNA-splicing endonuclease subunit Sen15
- Experimental structures
- 7
- Predicted models
- 1
- Pockets
- 19 · 3 records with a druggable one
Structures
8 records of Q8WW01 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2GW6 | NMR structure of the human tRNA endonuclease SEN15 subunit | solution nmr | A, B | — | — |
| 2GW6 | NMR structure of the human tRNA endonuclease SEN15 subunit | solution nmr | A, B | — | — |
| 6Z9U | Crystal structure of a TSEN15-34 heterodimer. | x-ray diffraction | B, D | — | 5 (best 0.50) |
| 6Z9U | Crystal structure of a TSEN15-34 heterodimer. | x-ray diffraction | B, D | — | — |
| 7UXA | Human tRNA Splicing Endonuclease Complex bound to pre-tRNA-ARG | electron microscopy | B | — | 6 (best 0.71) |
| 7ZRZ | Structure of the human tRNA splicing endonuclease defines substrate recognition | electron microscopy | DP1 | — | 4 (best 0.68) |
| 8ISS | Cryo-EM structure of wild-type human tRNA Splicing Endonuclease Complex bound to pre-tRNA-ARG at… | electron microscopy | A | — | 4 (best 0.69) |
| Q8WW01 | AlphaFold monomer V2.0 prediction for tRNA-splicing endonuclease subunit SEN15 (Q8WW01) | predicted | A | — | — |
Experiment against prediction
- 8ISS chain A against the predicted model Q8WW01: TM-score 0.96, RMSD 0.93 Å
- 7UXA chain B against the predicted model Q8WW01: TM-score 0.95, RMSD 1.04 Å
- 6Z9U chain B against the predicted model Q8WW01: TM-score 0.95, RMSD 1.08 Å
- 6Z9U chain B against the predicted model Q8WW01: TM-score 0.95, RMSD 1.08 Å
- 6Z9U chain D against the predicted model Q8WW01: TM-score 0.91, RMSD 1.75 Å
- 6Z9U chain D against the predicted model Q8WW01: TM-score 0.91, RMSD 1.75 Å
- 7ZRZ chain DP1 against the predicted model Q8WW01: TM-score 0.91, RMSD 1.48 Å
- 2GW6 chain A against the predicted model Q8WW01: TM-score 0.83, RMSD 2.11 Å
- 2GW6 chain A against the predicted model Q8WW01: TM-score 0.83, RMSD 2.11 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.