UniProt Q8WVK2
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (Q8WVK2)
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein (UniProt Q8WVK2): 10 experimental structures and 1 predicted model on GenesisL1, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8WVK2
- Protein
- U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 4 · 3 records with a druggable one
Structures
11 records of Q8WVK2 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6QW6 | Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution. | electron microscopy | X | — | 1 (best 0.78) |
| 6QX9 | Structure of a human fully-assembled precatalytic spliceosome (pre-B complex). | electron microscopy | X | — | — |
| 8H6E | Cryo-EM structure of human exon-defined spliceosome in the late pre-B state. | electron microscopy | 4X | — | 2 (best 0.81) |
| 8H6J | Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state. | electron microscopy | 4X | — | — |
| 8QP8 | Cryo-EM Structure of Pre-B Complex (core part) | electron microscopy | X | — | — |
| 8QP9 | Cryo-EM Structure of Pre-B+AMPPNP Complex (core part) | electron microscopy | X | — | — |
| 8QPK | Cryo-EM Structure of Pre-B+5'ss Complex (core part) | electron microscopy | X | — | — |
| 8QXD | Cryo-EM structure of the cross-exon pre-B complex | electron microscopy | X | — | — |
| 8R08 | Cryo-EM structure of the cross-exon pre-B+AMPPNP complex | electron microscopy | X | — | 1 (best 0.85) |
| 8R0A | Cryo-EM structure of the cross-exon pre-B+5'ss complex | electron microscopy | X | — | — |
| Q8WVK2 | AlphaFold monomer V2.0 prediction for U4/U6.U5 small nuclear ribonucleoprotein 27 kda protein… | predicted | A | — | — |
Experiment against prediction
- 8QXD chain X against the predicted model Q8WVK2: TM-score 0.34, RMSD 2.45 Å
- 6QW6 chain X against the predicted model Q8WVK2: TM-score 0.29, RMSD 3.51 Å
- 6QX9 chain X against the predicted model Q8WVK2: TM-score 0.29, RMSD 3.51 Å
- 8QP8 chain X against the predicted model Q8WVK2: TM-score 0.29, RMSD 1.91 Å
- 8QP9 chain X against the predicted model Q8WVK2: TM-score 0.23, RMSD 2.92 Å
- 8R08 chain X against the predicted model Q8WVK2: TM-score 0.23, RMSD 2.28 Å
- 8H6E chain 4X against the predicted model Q8WVK2: TM-score 0.23, RMSD 2.40 Å
- 8R0A chain X against the predicted model Q8WVK2: TM-score 0.22, RMSD 2.52 Å
- 8QPK chain X against the predicted model Q8WVK2: TM-score 0.22, RMSD 2.52 Å
- 8H6J chain 4X against the predicted model Q8WVK2: TM-score 0.18, RMSD 2.45 Å
Elsewhere
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