UniProt Q8WVC0
RNA polymerase-associated protein LEO1 (Q8WVC0)
RNA polymerase-associated protein LEO1 (UniProt Q8WVC0): 19 experimental structures on GenesisL1, 9 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q8WVC0
- Protein
- RNA polymerase-associated protein LEO1
- Experimental structures
- 19
- Predicted models
- 0
- Pockets
- 9 · 6 records with a druggable one
Structures
19 records of Q8WVC0 in the MolNFT archive: 19 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4M6T | Structure of human Paf1 and Leo1 complex | x-ray diffraction | A | — | — |
| 4M6T | Structure of human PAF1 and LEO1 complex | x-ray diffraction | A | — | — |
| 6GMH | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6 | electron microscopy | U | — | — |
| 6GMH | Structure of activated transcription complex pol II-dsif-paf-SPT6 | electron microscopy | U | — | — |
| 6TED | Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers allosteric… | electron microscopy | U | — | 2 (best 0.73) |
| 6TED | Structure of complete, activated transcription complex pol II-dsif- paf-SPT6 uncovers allosteric… | electron microscopy | U | — | — |
| 7OOP | Pol II-CSB-CSA-DDB1-UVSSA-PAF-SPT6 (Structure 3) | electron microscopy | U | — | — |
| 7OOP | Pol II-csb-csa-DDB1-uvssa-paf-SPT6 (structure 3) | electron microscopy | U | — | — |
| 7OPC | Pol II-CSB-CRL4CSA-UVSSA-SPT6-PAF (Structure 4) | electron microscopy | U | — | — |
| 7OPC | Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 4) | electron microscopy | U | — | — |
| 7OPD | Pol II-csb-CRL4CSA-uvssa-SPT6-paf (structure 5) | electron microscopy | U | — | — |
| 7UNC | Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome | electron microscopy | U | — | — |
| 7UND | Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) | electron microscopy | U | — | 1 (best 0.74) |
| 8A3Y | Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex | electron microscopy | Q, U | — | 3 (best 0.84) |
| 9EGX | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27 | electron microscopy | U | — | 1 (best 0.76) |
| 9EGY | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27 | electron microscopy | U | — | 1 (best 0.76) |
| 9EGZ | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-nucleosome, bp +27 | electron microscopy | U | — | 1 (best 0.84) |
| 9EH2 | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-SETD2-FACT nucleosome upstream | electron microscopy | U | — | — |
| Q8WVC0 | AlphaFold monomer V2.0 prediction for RNA polymerase-associated protein LEO1 (Q8WVC0) | — | — | — |
Experiment against prediction
- 8A3Y chain Q against the predicted model Q6PD62: TM-score 0.90, RMSD 3.46 Å
- 8A3Y chain U against the predicted model Q6PD62: TM-score 0.27, RMSD 5.09 Å
Elsewhere
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