UniProt Q8VDF2
E3 ubiquitin-protein ligase UHRF1 (Q8VDF2)
E3 ubiquitin-protein ligase UHRF1 (UniProt Q8VDF2), EC 2.3.2.27: 26 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q8VDF2
- Protein
- E3 ubiquitin-protein ligase UHRF1
- EC
- 2.3.2.27
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 13 · 1 record with a druggable one
Structures
27 records of Q8VDF2 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2ZKD | Crystal structure of the SRA domain of mouse Np95 in complex with hemi-methylated CpG DNA | x-ray diffraction | A, B | — | — |
| 2ZKD | Crystal structure of the sra domain of mouse NP95 in complex with hemi-methylated cpg DNA | x-ray diffraction | A, B | — | — |
| 2ZKE | Crystal structure of the SRA domain of mouse Np95 in complex with hemi-methylated CpG DNA | x-ray diffraction | A | — | — |
| 2ZKE | Crystal structure of the sra domain of mouse NP95 in complex with hemi-methylated cpg DNA | x-ray diffraction | A | — | — |
| 2ZKF | Crystal structure of the SRA domain of mouse Np95 in complex with hemi-methylated CpG DNA | x-ray diffraction | A | — | — |
| 2ZKF | Crystal structure of the sra domain of mouse NP95 in complex with hemi-methylated cpg DNA | x-ray diffraction | A | — | — |
| 2ZKG | Crystal structure of unliganded SRA domain of mouse Np95 | x-ray diffraction | A, B, C, D | — | — |
| 2ZKG | Crystal structure of unliganded sra domain of mouse NP95 | x-ray diffraction | A, B, C, D | — | — |
| 2ZO0 | mouse NP95 SRA domain DNA specific complex 1 | x-ray diffraction | B | — | — |
| 2ZO0 | Mouse NP95 sra domain DNA specific complex 1 | x-ray diffraction | B | — | — |
| 2ZO1 | Mouse NP95 SRA domain DNA specific complex 2 | x-ray diffraction | B | — | — |
| 2ZO1 | Mouse NP95 sra domain DNA specific complex 2 | x-ray diffraction | B | — | — |
| 2ZO2 | Mouse NP95 SRA domain non-specific DNA complex | x-ray diffraction | B | — | — |
| 2ZO2 | Mouse NP95 sra domain non-specific DNA complex | x-ray diffraction | B | — | — |
| 3F8I | Mouse UHRF1 SRA domain bound with hemi-methylated CpG, crystal structure in space group P21 | x-ray diffraction | A, B | — | — |
| 3F8I | Mouse UHRF1 sra domain bound with hemi-methylated cpg, crystal structure in space group P21 | x-ray diffraction | A, B | — | — |
| 3F8J | Mouse UHRF1 SRA domain bound with hemi-methylated CpG, crystal structure in space group C222(1) | x-ray diffraction | B | — | — |
| 3F8J | Mouse UHRF1 sra domain bound with hemi-methylated cpg, crystal structure in space group C222(1) | x-ray diffraction | B | — | — |
| 3FDE | Mouse UHRF1 SRA domain bound with hemi-methylated CpG DNA, crystal structure in space group C222(1)… | x-ray diffraction | A, B | — | — |
| 3FDE | Mouse UHRF1 sra domain bound with hemi-methylated cpg DNA, crystal structure in space group C222(1)… | x-ray diffraction | A, B | — | — |
| 6M2V | Crystal structure of UHRF1 sra complexed with fully-mchg DNA. | x-ray diffraction | B, A | — | — |
| 6VEE | Solution structure of the TTD and linker region of mouse UHRF1 (NP95) | solution nmr | A | — | 1 (best 0.28) |
| 6VEE | Solution structure of the ttd and linker region of mouse UHRF1 (NP95) | solution nmr | A | — | — |
| 6VFO | Solution structure of the PHD of mouse UHRF1 (NP95) | solution nmr | A | ZN | — |
| 6VFO | Solution structure of the phd of mouse UHRF1 (NP95) | solution nmr | A | ZN | — |
| 7XGA | NMR strucutre of chimeric protein for model of PHD-Stella complex | solution nmr | A | ZN | 2 (best 0.41) |
| Q8VDF2 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase UHRF1 (Q8VDF2) | predicted | A | — | 10 (best 0.63) |
Ligands
- ZN · Zinc ion · in 3 records
Experiment against prediction
- 2ZKD chain A against the predicted model Q8VDF2: TM-score 0.99, RMSD 0.68 Å
- 2ZKD chain A against the predicted model Q8VDF2: TM-score 0.99, RMSD 0.68 Å
- 2ZKD chain B against the predicted model Q8VDF2: TM-score 0.98, RMSD 0.72 Å
- 2ZKD chain B against the predicted model Q8VDF2: TM-score 0.98, RMSD 0.72 Å
- 2ZKF chain A against the predicted model Q8VDF2: TM-score 0.98, RMSD 0.71 Å
- 2ZKF chain A against the predicted model Q8VDF2: TM-score 0.98, RMSD 0.71 Å
- 3FDE chain B against the predicted model Q8VDF2: TM-score 0.98, RMSD 0.71 Å
- 3FDE chain B against the predicted model Q8VDF2: TM-score 0.98, RMSD 0.71 Å
- 2ZKE chain A against the predicted model Q8VDF2: TM-score 0.98, RMSD 0.72 Å
- 2ZKE chain A against the predicted model Q8VDF2: TM-score 0.98, RMSD 0.72 Å
Elsewhere
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