GL1X · GenesisL1 explorer

UniProt Q8ULI9

Protease NL4-3 (Q8ULI9)

Protease NL4-3 (UniProt Q8ULI9): 108 experimental structures on GenesisL1, 54 ligands bound, 114 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.

UniProt
Q8ULI9
Protein
Protease NL4-3
Experimental structures
108
Predicted models
0
Ligands
54
Pockets
114 · 108 records with a druggable one

Structures

108 records of Q8ULI9 in the MolNFT archive: 108 experimental, 0 predicted.

EntryTitleMethodChainsLigandsPockets
6DGXCrystal structure of HIV-1 Protease NL4-3 WT in complex with darunavirx-ray diffractionB, A017, SO41 (best 0.71)
6DGXCrystal structure of HIV-1 protease NL4-3 wt in complex with darunavirx-ray diffractionB, A017, SO41 (best 0.71)
6DGYCrystal structure of HIV-1 Protease NL4-3 WT in complex with UMass1x-ray diffractionB, ASO4, K131 (best 0.72)
6DGYCrystal structure of HIV-1 protease NL4-3 wt in complex with UMASS1x-ray diffractionB, ASO4, K131 (best 0.72)
6DGZCrystal structure of HIV-1 Protease NL4-3 WT in complex with UMass6x-ray diffractionB, ASO4, A601 (best 0.73)
6DGZCrystal structure of HIV-1 protease NL4-3 wt in complex with UMASS6x-ray diffractionB, ASO4, A601 (best 0.73)
6OPSHIV-1 Protease NL4-3 WT in complex with darunavirx-ray diffractionB, A0171 (best 0.71)
6OPSHIV-1 protease NL4-3 wt in complex with darunavirx-ray diffractionB, A0171 (best 0.71)
6OXOHIV-1 Protease NL4-3 WT in Complex with LR2-91x-ray diffractionB, ASO4, NJM1 (best 0.71)
6OXOHIV-1 protease NL4-3 wt in complex with LR2-91x-ray diffractionB, ASO4, NJM1 (best 0.71)
6OXPHIV-1 Protease NL4-3 WT in Complex with UMass3x-ray diffractionB, ASO4, K2A1 (best 0.71)
6OXPHIV-1 protease NL4-3 wt in complex with UMASS3x-ray diffractionB, ASO4, K2A1 (best 0.71)
6OXQHIV-1 Protease NL4-3 WT in Complex with UMass8x-ray diffractionB, ASO4, F531 (best 0.72)
6OXQHIV-1 protease NL4-3 wt in complex with UMASS8x-ray diffractionB, ASO4, F531 (best 0.72)
6OXRHIV-1 Protease NL4-3 WT in Complex with LR-82x-ray diffractionB, ANJA1 (best 0.71)
6OXRHIV-1 protease NL4-3 wt in complex with lr-82x-ray diffractionB, ANJA1 (best 0.71)
6OXSHIV-1 Protease NL4-3 WT in Complex with LR-76x-ray diffractionB, ANJ41 (best 0.71)
6OXSHIV-1 protease NL4-3 wt in complex with lr-76x-ray diffractionB, ANJ41 (best 0.71)
6OXTHIV-1 Protease NL4-3 WT in Complex with LR-84x-ray diffractionB, ASO4, NEJ1 (best 0.72)
6OXTHIV-1 protease NL4-3 wt in complex with lr-84x-ray diffractionB, ASO4, NEJ1 (best 0.72)
6OXUHIV-1 Protease NL4-3 WT in Complex with LR-99x-ray diffractionB, ASO4, NE71 (best 0.70)
6OXUHIV-1 protease NL4-3 wt in complex with lr-99x-ray diffractionB, ASO4, NE71 (best 0.70)
6OXVHIV-1 Protease NL4-3 WT in Complex with LR-85x-ray diffractionB, ANF41 (best 0.70)
6OXVHIV-1 protease NL4-3 wt in complex with lr-85x-ray diffractionB, ANF41 (best 0.70)
6OXWHIV-1 Protease NL4-3 WT in Complex with LR-100x-ray diffractionB, ANFJ1 (best 0.71)
6OXWHIV-1 protease NL4-3 wt in complex with lr-100x-ray diffractionB, ANFJ1 (best 0.71)
6OXXHIV-1 Protease NL4-3 WT in Complex with LR2-18x-ray diffractionB, ANF71 (best 0.72)
6OXXHIV-1 protease NL4-3 wt in complex with LR2-18x-ray diffractionB, ANF71 (best 0.72)
6OXYHIV-1 Protease NL4-3 WT in Complex with LR2-19x-ray diffractionB, ASO4, NG41 (best 0.72)
6OXYHIV-1 protease NL4-3 wt in complex with LR2-19x-ray diffractionB, ASO4, NG41 (best 0.72)
6OXZHIV-1 Protease NL4-3 WT in Complex with LR2-20x-ray diffractionB, ASO4, NJG1 (best 0.72)
6OXZHIV-1 protease NL4-3 wt in complex with LR2-20x-ray diffractionB, ASO4, NJG1 (best 0.72)
6OY0HIV-1 Protease NL4-3 WT in Complex with LR2-21x-ray diffractionB, ASO4, NJ71 (best 0.71)
6OY0HIV-1 protease NL4-3 wt in complex with LR2-21x-ray diffractionB, ASO4, NJ71 (best 0.71)
6OY1HIV-1 Protease NL4-3 WT in Complex with LR2-26x-ray diffractionB, ASO4, NJ11 (best 0.72)
6OY1HIV-1 protease NL4-3 wt in complex with LR2-26x-ray diffractionB, ASO4, NJ11 (best 0.72)
6OY2HIV-1 Protease NL4-3 WT in Complex with LR2-25x-ray diffractionB, ANJJ, SO41 (best 0.72)
6OY2HIV-1 protease NL4-3 wt in complex with LR2-25x-ray diffractionB, ANJJ, SO41 (best 0.72)
6PJBHIV-1 Protease NL4-3 WT in Complex with Lopinavirx-ray diffractionB, ASO4, AB11 (best 0.71)
6PJBHIV-1 protease NL4-3 wt in complex with lopinavirx-ray diffractionB, ASO4, AB11 (best 0.71)
6PJCHIV-1 Protease NL4-3 WT in Complex with LR4-41x-ray diffractionB, A, D, CSO4, OR14 (best 0.71)
6PJCHIV-1 protease NL4-3 wt in complex with LR4-41x-ray diffractionB, A, D, CSO4, OR14 (best 0.71)
6PJDHIV-1 Protease NL4-3 WT in Complex with LR2-32x-ray diffractionB, ASO4, OQY1 (best 0.72)
6PJDHIV-1 protease NL4-3 wt in complex with LR2-32x-ray diffractionB, ASO4, OQY1 (best 0.72)
6PJEHIV-1 Protease NL4-3 WT in Complex with LR2-43x-ray diffractionB, AOPJ, SO41 (best 0.71)
6PJEHIV-1 protease NL4-3 wt in complex with LR2-43x-ray diffractionB, AOPJ, SO41 (best 0.71)
6PJFHIV-1 Protease NL4-3 WT in Complex with LR2-44x-ray diffractionB, ASO4, OP71 (best 0.73)
6PJFHIV-1 protease NL4-3 wt in complex with LR2-44x-ray diffractionB, ASO4, OP71 (best 0.73)
6PJGHIV-1 Protease NL4-3 WT in Complex with LR3-97x-ray diffractionB, AORV1 (best 0.71)
6PJGHIV-1 protease NL4-3 wt in complex with LR3-97x-ray diffractionB, AORV1 (best 0.71)
6PJHHIV-1 Protease NL4-3 WT in Complex with LR3-28x-ray diffractionB, AOQG, SO41 (best 0.71)
6PJHHIV-1 protease NL4-3 wt in complex with LR3-28x-ray diffractionB, AOQG, SO41 (best 0.71)
6PJIHIV-1 Protease NL4-3 WT in Complex with LR3-43x-ray diffractionB, AOO4, SO41 (best 0.71)
6PJIHIV-1 protease NL4-3 wt in complex with LR3-43x-ray diffractionB, AOO4, SO41 (best 0.71)
6PJKHIV-1 Protease NL4-3 WT in Complex with LR3-29x-ray diffractionB, AOQD, SO41 (best 0.71)
6PJKHIV-1 protease NL4-3 wt in complex with LR3-29x-ray diffractionB, AOQD, SO41 (best 0.71)
6PJLHIV-1 Protease NL4-3 WT in Complex with LR3-95x-ray diffractionB, ASO4, OQA1 (best 0.73)
6PJLHIV-1 protease NL4-3 wt in complex with LR3-95x-ray diffractionB, ASO4, OQA1 (best 0.73)
6PJMHIV-1 Protease NL4-3 WT in Complex with LR2-35x-ray diffractionA, BSO4, OQV1 (best 0.71)
6PJMHIV-1 protease NL4-3 wt in complex with LR2-35x-ray diffractionA, BSO4, OQV1 (best 0.71)

48 records more on the page itself.

Ligands

  • SO4 · Sulfate ion · in 92 records
  • 017 · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl(1s,2r)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzyl-2-hydroxypropylcarbamate · in 4 records
  • 065 · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl(2s,3r)-3-hydroxy-4-(N-isobutylbenzo[d][1,3]dioxole-5-sulfonamido)-1-phenylbutan-2-ylcarbamate · in 2 records
  • A60 · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-ethylbutyl)amino}-1-benzyl-2-hydroxypropyl]carbamate · in 2 records
  • A61 · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(1S,2R)-3-[(1,3-benzothiazol-6-ylsulfonyl)(2-ethylbutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate · in 2 records
  • AB1 · N-{1-benzyl-4-[2-(2,6-dimethyl-phenoxy)-acetylamino]-3-hydroxy-5-phenyl-pentyl}-3-methyl-2-(2-oxo-tetrahydro-pyrimidin-1-yl)-butyramide · in 2 records
  • DJR · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{isobutyl[(4-methoxyphenyl) sulfonyl]amino}propyl]carbamate · in 2 records
  • F53 · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl {(1S,2R)-1-benzyl-3-[(2-ethylbutyl){[4-(hydroxymethyl) phenyl]sulfonyl}amino]-2-hydroxypropyl}carbamate · in 2 records
  • K13 · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate · in 2 records
  • K14 · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-{[(4-methoxyphenyl)sulfonyl][(2S)-2-methylbutyl]amino}propyl]carbamate · in 2 records
  • K19 · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{(1,3-benzothiazol-6-ylsulfonyl)[(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate · in 2 records
  • K20 · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{(1,3-benzodioxol-5-ylsulfonyl)[(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate · in 2 records
  • K2A · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-1-benzyl-2-hydroxy-3-({[4-(hydroxymethyl) phenyl]sulfonyl}[(2s)-2-methylbutyl]amino) propyl]carbamate · in 2 records
  • K2D · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-1-benzyl-3-{(2-ethylbutyl)[(4-methoxyphenyl) sulfonyl]amino}-2-hydroxypropyl]carbamate · in 2 records
  • K2E · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(1S,2R)-3-[(1,3-benzodioxol-5-ylsulfonyl)(2-ethylbutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate · in 2 records
  • KGQ · Diethyl ({4-[(2S,3R)-2-({[(3r,3as,6ar)-hexahydrofuro[2, 3-b]furan-3-yloxy]carbonyl}amino)-3-hydroxy-4-{isobutyl[(4-methoxyphenyl) sulfonyl]amino}butyl]phenoxy}methyl)phosphonate · in 2 records
  • NE7 · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-{({4-[(1R)-1-hydroxyethyl]phenyl}sulfonyl) [(2S)-2-methylbutyl]amino}-1-phenylbutan-2-yl]carbamate · in 2 records
  • NEJ · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-{({4-[(1S)-1-hydroxyethyl]phenyl}sulfonyl) [(2S)-2-methylbutyl]amino}-1-phenylbutan-2-yl]carbamate · in 2 records
  • NF4 · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-[(2-ethylbutyl)({4-[(1S)-1-hydroxyethyl]phenyl}sulfonyl)amino]-3-hydroxy-1-phenylbutan-2-yl}carbamate · in 2 records
  • NF7 · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-[({4-[(1R)-1,2-dihydroxyethyl]phenyl}sulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl}carbamate · in 2 records
  • NFJ · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-[(2-ethylbutyl)({4-[(1R)-1-hydroxyethyl]phenyl}sulfonyl)amino]-3-hydroxy-1-phenylbutan-2-yl}carbamate · in 2 records
  • NG4 · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-[({4-[(1S)-1,2-dihydroxyethyl]phenyl}sulfonyl)(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl}carbamate · in 2 records
  • NJ1 · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-[({4-[(1R)-1,2-dihydroxyethyl]phenyl}sulfonyl)(2-ethylbutyl)amino]-3-hydroxy-1-phenylbutan-2-yl}carbamate · in 2 records
  • NJ4 · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-3-hydroxy-4-[({4-[(1R)-1-hydroxyethyl]phenyl}sulfonyl) (2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate · in 2 records
  • NJ7 · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{({4-[(1S)-1,2-dihydroxyethyl]phenyl}sulfonyl)[(2S)-2-methylbutyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate · in 2 records
  • NJA · (3r,3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-3-hydroxy-4-[({4-[(1S)-1-hydroxyethyl]phenyl}sulfonyl) (2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate · in 2 records
  • NJG · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{({4-[(1R)-1,2-dihydroxyethyl]phenyl}sulfonyl)[(2S)-2-methylbutyl]amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate · in 2 records
  • NJJ · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-4-[({4-[(1S)-1,2-dihydroxyethyl]phenyl}sulfonyl)(2-ethylbutyl)amino]-3-hydroxy-1-phenylbutan-2-yl}carbamate · in 2 records
  • NJM · (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-3-hydroxy-4-[{[4-(hydroxymethyl)phenyl]sulfonyl}(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate · in 2 records
  • OO4 · Methyl [(1S)-1-cyclopropyl-2-({(2S,3S,5S)-5-[({[(3R, 3as,6ar)-hexahydrofuro[2,3-b]furan-3-yl]oxy}carbonyl) amino]-3-hydroxy-1,6-diphenylhexan-2-yl}amino)-2-oxoethyl]carbamate · in 2 records

Elsewhere

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