UniProt Q8U0M5
DNA-directed RNA polymerase subunit Rpo1C (Q8U0M5)
DNA-directed RNA polymerase subunit Rpo1C (UniProt Q8U0M5), EC 2.7.7.6: 7 experimental structures and 1 predicted model on GenesisL1, 43 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8U0M5
- Protein
- DNA-directed RNA polymerase subunit Rpo1C
- EC
- 2.7.7.6
- Experimental structures
- 7
- Predicted models
- 1
- Pockets
- 43 · 6 records with a druggable one
Structures
8 records of Q8U0M5 in the MolNFT archive: 7 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3QQC | Crystal structure of archaeal Spt4/5 bound to the RNAP clamp domain | x-ray diffraction | A | — | — |
| 3QQC | Crystal structure of archaeal SPT4/5 bound to the rnap clamp domain | x-ray diffraction | A | — | — |
| 8CRO | Cryo-EM structure of Pyrococcus furiosus transcription elongation complex | electron microscopy | C | — | 8 (best 0.84) |
| 8OKI | Cryo-EM structure of Pyrococcus furiosus transcription elongation complex bound to Spt4/5 | electron microscopy | C | — | 7 (best 0.82) |
| 8ORQ | Cryo-EM structure of Pyrococcus furiosus apo form RNA polymerase open clamp conformation | electron microscopy | C | — | 8 (best 0.68) |
| 8P2I | Cryo-EM structure of Pyrococcus furiosus apo form RNA polymerase contracted clamp conformation with… | electron microscopy | C | — | 8 (best 0.73) |
| 8RBO | Cryo-EM structure of Pyrococcus furiosus apo form RNA polymerase contracted clamp conformation | electron microscopy | C | — | 9 (best 0.70) |
| Q8U0M5 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit a'' (Q8U0M5) | predicted | A | — | 3 (best 0.64) |
Experiment against prediction
- 8CRO chain C against the predicted model Q8U0M5: TM-score 0.95, RMSD 1.80 Å
- 8RBO chain C against the predicted model Q8U0M5: TM-score 0.94, RMSD 1.98 Å
- 8P2I chain C against the predicted model Q8U0M5: TM-score 0.93, RMSD 2.11 Å
- 8OKI chain C against the predicted model Q8U0M5: TM-score 0.93, RMSD 2.25 Å
- 8ORQ chain C against the predicted model Q8U0M5: TM-score 0.89, RMSD 2.64 Å
- 3QQC chain A against the predicted model Q8U0M5: TM-score 0.21, RMSD 6.54 Å
- 3QQC chain A against the predicted model Q8U0M5: TM-score 0.21, RMSD 6.54 Å
Elsewhere
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