UniProt Q8U094
Tryptophan synthase alpha chain (Q8U094)
Tryptophan synthase alpha chain (UniProt Q8U094), EC 4.2.1.20: 22 experimental structures and 1 predicted model on GenesisL1, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8U094
- Protein
- Tryptophan synthase alpha chain
- EC
- 4.2.1.20
- Experimental structures
- 22
- Predicted models
- 1
- Pockets
- 17 · 2 records with a druggable one
Structures
23 records of Q8U094 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GEQ | Entropic stabilization of the tryptophan synthase A-subunit from a hyperthermophile, pyrococcus… | x-ray diffraction | A, B | — | — |
| 1GEQ | Entropic stabilization of the tryptophan synthase a-subunit from a hyperthermophile, pyrococcus… | x-ray diffraction | A, B | — | — |
| 1WDW | Structural basis of mutual activation of the tryptophan synthase a2b2 complex from a… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1WDW | Structural basis of mutual activation of the tryptophan synthase A2B2 complex from a… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 2DZP | Structure of mutant tryptophan synthase alpha-subunit (D17N) from a hyperthermophile, Pyrococcus… | x-ray diffraction | A, B | — | — |
| 2DZP | Structure of mutant tryptophan synthase alpha-subunit (D17N) from a hyperthermophile, pyrococcus… | x-ray diffraction | A, B | — | — |
| 2DZS | Structure of mutant tryptophan synthase alpha-subunit (E103A) from a hyperthermophile, Pyrococcus… | x-ray diffraction | A, B | — | — |
| 2DZS | Structure of mutant tryptophan synthase alpha-subunit (E103A) from a hyperthermophile, pyrococcus… | x-ray diffraction | A, B | — | — |
| 2DZT | Structure of mutant tryptophan synthase alpha-subunit (D110A) from a hyperthermophile, Pyrococcus… | x-ray diffraction | A, B | — | — |
| 2DZT | Structure of mutant tryptophan synthase alpha-subunit (D110A) from a hyperthermophile, pyrococcus… | x-ray diffraction | A, B | — | — |
| 2DZU | Structure of mutant tryptophan synthase alpha-subunit (D110N) from a hyperthermophile, Pyrococcus… | x-ray diffraction | A, B | — | — |
| 2DZU | Structure of mutant tryptophan synthase alpha-subunit (D110N) from a hyperthermophile, pyrococcus… | x-ray diffraction | A, B | — | — |
| 2DZV | Structure of mutant tryptophan synthase alpha-subunit (D146A) from a hyperthermophile, Pyrococcus… | x-ray diffraction | A, B | — | — |
| 2DZV | Structure of mutant tryptophan synthase alpha-subunit (D146A) from a hyperthermophile, pyrococcus… | x-ray diffraction | A, B | — | — |
| 2DZW | Structure of mutant tryptophan synthase alpha-subunit (E244A) from a hyperthermophile, Pyrococcus… | x-ray diffraction | A, B | — | — |
| 2DZW | Structure of mutant tryptophan synthase alpha-subunit (E244A) from a hyperthermophile, pyrococcus… | x-ray diffraction | A, B | — | — |
| 2DZX | Structure of mutant tryptophan synthase alpha-subunit (E131-132A) from a hyperthermophile… | x-ray diffraction | A, B | — | — |
| 2DZX | Structure of mutant tryptophan synthase alpha-subunit (E131-132A) from a hyperthermophile… | x-ray diffraction | A, B | — | — |
| 2E09 | Structure of mutant tryptophan synthase alpha-subunit (E74A) from a hyperthermophile, Pyrococcus… | x-ray diffraction | A, B | — | — |
| 2E09 | Structure of mutant tryptophan synthase alpha-subunit (E74A) from a hyperthermophile, pyrococcus… | x-ray diffraction | A, B | — | — |
| 5E0K | X-ray crystal structure of tryptophan synthase complex from Pyrococcus furiosus at 2.76 A | x-ray diffraction | A, C, E, G, I, K | — | 15 (best 0.85) |
| 5E0K | X-ray crystal structure of tryptophan synthase complex from pyrococcus furiosus at 2.76 a | x-ray diffraction | A, C, E, G, I, K | — | — |
| Q8U094 | AlphaFold monomer V2.0 prediction for tryptophan synthase alpha chain (Q8U094) | predicted | A | — | 2 (best 0.67) |
Experiment against prediction
- 1WDW chain K against the predicted model Q8U094: TM-score 0.99, RMSD 0.55 Å
- 1WDW chain K against the predicted model Q8U094: TM-score 0.99, RMSD 0.55 Å
- 5E0K chain C against the predicted model Q8U094: TM-score 0.99, RMSD 0.59 Å
- 5E0K chain C against the predicted model Q8U094: TM-score 0.99, RMSD 0.59 Å
- 5E0K chain E against the predicted model Q8U094: TM-score 0.99, RMSD 0.58 Å
- 5E0K chain E against the predicted model Q8U094: TM-score 0.99, RMSD 0.58 Å
- 5E0K chain G against the predicted model Q8U094: TM-score 0.99, RMSD 0.59 Å
- 5E0K chain A against the predicted model Q8U094: TM-score 0.99, RMSD 0.59 Å
- 5E0K chain A against the predicted model Q8U094: TM-score 0.99, RMSD 0.59 Å
- 1WDW chain C against the predicted model Q8U094: TM-score 0.99, RMSD 0.61 Å
Elsewhere
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