UniProt Q8TZR3
protein-L-isoaspartate O-methyltransferase (Q8TZR3)
protein-L-isoaspartate O-methyltransferase (UniProt Q8TZR3), EC 2.1.1.77: 8 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8TZR3
- Protein
- protein-L-isoaspartate O-methyltransferase
- EC
- 2.1.1.77
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 7 · 5 records with a druggable one
Structures
9 records of Q8TZR3 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JG1 | Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with S-ADENOSYL-L-HOMOCYSTEINE | x-ray diffraction | A | SAH | 1 (best 0.72) |
| 1JG1 | Crystal structure of L-isoaspartyl (D-aspartyl) O- methyltransferase with S-adenosyl-L-homocysteine | x-ray diffraction | A | — | — |
| 1JG2 | Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with adenosine | x-ray diffraction | A | NA, ADN | 1 (best 0.75) |
| 1JG2 | Crystal structure of L-isoaspartyl (D-aspartyl) O- methyltransferase with adenosine | x-ray diffraction | A | — | — |
| 1JG3 | Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with adenosine & VYP(ISP)HA… | x-ray diffraction | A, B | CL, NA, ADN | 3 (best 0.78) |
| 1JG3 | Crystal structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with adenosine & VYP(ISP)HA… | x-ray diffraction | A, B | — | — |
| 1JG4 | Crystal Structure of L-isoaspartyl (D-aspartyl) O-methyltransferase with S-adenosylmethionine | x-ray diffraction | A | SAM | 1 (best 0.70) |
| 1JG4 | Crystal structure of L-isoaspartyl (D-aspartyl) O- methyltransferase with S-adenosylmethionine | x-ray diffraction | A | — | — |
| Q8TZR3 | AlphaFold monomer V2.0 prediction for protein-L-isoaspartate O-methyltransferase (Q8TZR3) | predicted | A | — | 1 (best 0.71) |
Ligands
Experiment against prediction
- 1JG2 chain A against the predicted model Q8TZR3: TM-score 1.00, RMSD 0.25 Å
- 1JG2 chain A against the predicted model Q8TZR3: TM-score 1.00, RMSD 0.25 Å
- 1JG1 chain A against the predicted model Q8TZR3: TM-score 1.00, RMSD 0.25 Å
- 1JG1 chain A against the predicted model Q8TZR3: TM-score 0.99, RMSD 0.25 Å
- 1JG4 chain A against the predicted model Q8TZR3: TM-score 0.99, RMSD 0.50 Å
- 1JG3 chain A against the predicted model Q8TZR3: TM-score 0.99, RMSD 0.51 Å
- 1JG3 chain A against the predicted model Q8TZR3: TM-score 0.99, RMSD 0.51 Å
- 1JG4 chain A against the predicted model Q8TZR3: TM-score 0.99, RMSD 0.50 Å
Elsewhere
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