UniProt Q8THH1
Methyl-coenzyme M reductase subunit alpha (Q8THH1)
Methyl-coenzyme M reductase subunit alpha (UniProt Q8THH1), EC 2.8.4.1: 2 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q8THH1
- Protein
- Methyl-coenzyme M reductase subunit alpha
- EC
- 2.8.4.1
- Experimental structures
- 2
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 11 · 1 record with a druggable one
Structures
3 records of Q8THH1 in the MolNFT archive: 2 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8GF5 | McrD binds asymmetrically to methyl-coenzyme M reductase improving active site accessibility during… | electron microscopy | A, B | COM, F43 | — |
| 8GF6 | Apo-apo MCR assembly intermediate | electron microscopy | A, B | — | 11 (best 0.85) |
| Q8THH1 | AlphaFold monomer V2.0 prediction for methyl-coenzyme M reductase subunit alpha (Q8THH1) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8GF5 chain A against the predicted model Q8THH1: TM-score 0.99, RMSD 0.76 Å
- 8GF6 chain A against the predicted model Q8THH1: TM-score 0.99, RMSD 0.98 Å
- 8GF5 chain B against the predicted model Q8THH1: TM-score 0.98, RMSD 1.15 Å
- 8GF6 chain B against the predicted model Q8THH1: TM-score 0.98, RMSD 1.23 Å
Elsewhere
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