UniProt Q8TDX7
Serine/threonine-protein kinase Nek7 (Q8TDX7)
Serine/threonine-protein kinase Nek7 (UniProt Q8TDX7), EC 2.7.11.1, 2.7.11.34: 16 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 74 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8TDX7
- Protein
- Serine/threonine-protein kinase Nek7
- EC
- 2.7.11.1, 2.7.11.34
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 74 · 7 records with a druggable one
Structures
17 records of Q8TDX7 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2WQM | Structure of apo human Nek7 | x-ray diffraction | A | — | — |
| 2WQM | Structure of apo human NEK7 | x-ray diffraction | A | — | — |
| 2WQN | Structure of ADP-bound human Nek7 | x-ray diffraction | A | — | — |
| 2WQN | Structure of ADP-bound human NEK7 | x-ray diffraction | A | — | — |
| 5DE2 | Structural mechanism of Nek7 activation by Nek9-induced dimerisation | x-ray diffraction | A, B | — | — |
| 5DE2 | Structural mechanism of NEK7 activation by NEK9-induced dimerisation | x-ray diffraction | A, B | — | — |
| 6NPY | Cryo-EM structure of NLRP3 bound to NEK7 | electron microscopy | B | — | 6 (best 0.88) |
| 6NPY | Cryo-EM structure of NLRP3 bound to NEK7 | electron microscopy | B | — | — |
| 6S73 | Crystal structure of Nek7 SRS mutant bound to compound 51 | x-ray diffraction | A, B, C, D | F9N | 14 (best 0.75) |
| 6S73 | Crystal structure of NEK7 srs mutant bound to compound 51 | x-ray diffraction | A, B, C, D | F9N | — |
| 6S75 | Crystal structure of Nek7 bound to compound 51 | x-ray diffraction | A, B, C, D | F9N | 13 (best 0.75) |
| 6S75 | Crystal structure of NEK7 bound to compound 51 | x-ray diffraction | A, B, C, D | F9N | — |
| 6S76 | Crystal structure of human Nek7 | x-ray diffraction | A, B, C, D | — | 12 (best 0.70) |
| 6S76 | Crystal structure of human NEK7 | x-ray diffraction | A, B, C, D | — | — |
| 8EJ4 | Cryo-EM structure of the active NLRP3 inflammasome disk | electron microscopy | K, L, M, N, O, P, Q, R, S, T | — | 13 (best 0.86) |
| 8SXN | Structure of NLRP3 and NEK7 complex | electron microscopy | A, B | — | 13 (best 0.85) |
| Q8TDX7 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase NEK7 (Q8TDX7) | predicted | A | — | 3 (best 0.67) |
Ligands
- F9N · 3-[[6-(cyclohexylmethoxy)-7~{H}-purin-2-yl]amino]-~{N}-[3-(dimethylamino)propyl]benzenesulfonamide · in 4 records
Experiment against prediction
- 8SXN chain B against the predicted model Q8TDX7: TM-score 0.96, RMSD 1.52 Å
- 5DE2 chain A against the predicted model Q8TDX7: TM-score 0.96, RMSD 1.39 Å
- 5DE2 chain A against the predicted model Q8TDX7: TM-score 0.96, RMSD 1.39 Å
- 8SXN chain A against the predicted model Q8TDX7: TM-score 0.96, RMSD 1.53 Å
- 5DE2 chain B against the predicted model Q8TDX7: TM-score 0.96, RMSD 1.34 Å
- 5DE2 chain B against the predicted model Q8TDX7: TM-score 0.96, RMSD 1.34 Å
- 2WQM chain A against the predicted model Q8TDX7: TM-score 0.96, RMSD 1.32 Å
- 2WQM chain A against the predicted model Q8TDX7: TM-score 0.96, RMSD 1.32 Å
- 2WQN chain A against the predicted model Q8TDX7: TM-score 0.96, RMSD 1.35 Å
- 2WQN chain A against the predicted model Q8TDX7: TM-score 0.96, RMSD 1.35 Å
Elsewhere
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