UniProt Q8TDW0
Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel subunit LRRC8A (Q8TDW0)
Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel subunit LRRC8A (UniProt Q8TDW0): 8 experimental structures and 1 predicted model on GenesisL1, 159 pockets. Binding sites, druggability and experiment…
- UniProt
- Q8TDW0
- Protein
- Volume-regulated anion channel subunit LRRC8C,Volume-regulated anion channel…
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 159 · 9 records with a druggable one
Structures
9 records of Q8TDW0 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8DXN | Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 1 | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.68) |
| 8DXO | Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 2 | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.68) |
| 8DXP | Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 3 | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.82) |
| 8DXQ | Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 4 | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.79) |
| 8DXR | Structure of LRRC8C-LRRC8A(IL125) Chimera, Class 5 | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.78) |
| 8RTS | Structure of a homomeric human LRRC8C Volume-Regulated Anion Channel | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.85) |
| 9EZC | Structure of the extracellular subdomain of a homomeric LRRC8C truncation disease mutant | electron microscopy | A, B, C, D, E, F, G | — | 16 (best 0.78) |
| 9F16 | Structure of a homomeric LRRC8C point mutation disease mutant | electron microscopy | A, B, C, D, E, F, G | — | 20 (best 0.88) |
| Q8TDW0 | AlphaFold monomer V2.0 prediction for volume-regulated anion channel subunit LRRC8C (Q8TDW0) | predicted | A | — | 3 (best 0.64) |
Experiment against prediction
- 8DXO chain F against the predicted model Q8TDW0: TM-score 0.98, RMSD 0.96 Å
- 8DXN chain C against the predicted model Q8TDW0: TM-score 0.98, RMSD 1.02 Å
- 8DXO chain C against the predicted model Q8TDW0: TM-score 0.98, RMSD 1.03 Å
- 8DXQ chain G against the predicted model Q8TDW0: TM-score 0.98, RMSD 1.03 Å
- 8DXN chain F against the predicted model Q8TDW0: TM-score 0.97, RMSD 1.07 Å
- 8DXQ chain F against the predicted model Q8TDW0: TM-score 0.97, RMSD 1.09 Å
- 8DXR chain G against the predicted model Q8TDW0: TM-score 0.97, RMSD 1.08 Å
- 8DXO chain G against the predicted model Q8TDW0: TM-score 0.97, RMSD 1.09 Å
- 8DXP chain F against the predicted model Q8TDW0: TM-score 0.97, RMSD 1.12 Å
- 8DXR chain A against the predicted model Q8TDW0: TM-score 0.97, RMSD 1.12 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.