UniProt Q8TBB1
E3 ubiquitin-protein ligase LNX (Q8TBB1)
E3 ubiquitin-protein ligase LNX (UniProt Q8TBB1), EC 6.3.2.-: 6 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q8TBB1
- Protein
- E3 ubiquitin-protein ligase LNX
- EC
- 6.3.2.-
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 1 · 0 records with a druggable one
Structures
7 records of Q8TBB1 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3B76 | Crystal structure of the third PDZ domain of human ligand-of-numb protein-X (LNX1) in complex with… | x-ray diffraction | A, B | — | — |
| 3B76 | Crystal structure of the third PDZ domain of human ligand-of-numb protein-X (LNX1) in complex with… | x-ray diffraction | A, B | — | — |
| 5H7R | Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1… | x-ray diffraction | D | ZN | 1 (best 0.26) |
| 5H7R | Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1… | x-ray diffraction | D | — | — |
| 5H7S | Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1… | x-ray diffraction | D, B | ZN | — |
| 5H7S | Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1… | x-ray diffraction | D, B | — | — |
| Q8TBB1 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase lnx (Q8TBB1) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 2 records
Experiment against prediction
- 5H7R chain D against the predicted model Q8TBB1: TM-score 0.98, RMSD 0.86 Å
- 5H7R chain D against the predicted model Q8TBB1: TM-score 0.98, RMSD 0.86 Å
- 5H7S chain D against the predicted model Q8TBB1: TM-score 0.98, RMSD 0.85 Å
- 5H7S chain D against the predicted model Q8TBB1: TM-score 0.98, RMSD 0.85 Å
- 3B76 chain A against the predicted model Q8TBB1: TM-score 0.88, RMSD 2.04 Å
- 3B76 chain A against the predicted model Q8TBB1: TM-score 0.88, RMSD 2.04 Å
- 3B76 chain B against the predicted model Q8TBB1: TM-score 0.85, RMSD 2.23 Å
- 3B76 chain B against the predicted model Q8TBB1: TM-score 0.85, RMSD 2.23 Å
Elsewhere
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