UniProt Q8R418
Endoribonuclease Dicer (Q8R418)
Endoribonuclease Dicer (UniProt Q8R418), EC 3.1.26.3: 10 experimental structures and 1 predicted model on GenesisL1, 83 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8R418
- Protein
- Endoribonuclease Dicer
- EC
- 3.1.26.3
- Experimental structures
- 10
- Predicted models
- 1
- Pockets
- 83 · 5 records with a druggable one
Structures
11 records of Q8R418 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3C4B | Structure of RNaseIIIb and dsRNA binding domains of mouse Dicer | x-ray diffraction | A | — | — |
| 3C4B | Structure of rnaseiiib and dsrna binding domains of mouse dicer | x-ray diffraction | A | — | — |
| 3C4T | Structure of RNaseIIIb and dsRNA binding domains of mouse Dicer | x-ray diffraction | A | — | — |
| 3C4T | Structure of rnaseiiib and dsrna binding domains of mouse dicer | x-ray diffraction | A | — | — |
| 7YYM | Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate | electron microscopy | A | — | 20 (best 0.79) |
| 7YYN | Mammalian Dicer in the dicing state with pre-miR-15a substrate | electron microscopy | A | — | 11 (best 0.78) |
| 7YZ4 | Mouse endoribonuclease Dicer (composite structure) | electron microscopy | A | — | 20 (best 0.77) |
| 7ZPI | Mammalian Dicer in the "dicing state" with pre-miR-15a substrate | electron microscopy | A | — | 12 (best 0.79) |
| 7ZPJ | Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate and TARBP2 subunit | electron microscopy | A | — | 20 (best 0.78) |
| 7ZPK | Mammalian Dicer in the "pre-dicing state" with pre-miR-15a substrate and TARBP2 subunit | electron microscopy | A | — | — |
| Q8R418 | AlphaFold monomer V2.0 prediction for endoribonuclease dicer (Q8R418) | predicted | A | — | — |
Experiment against prediction
- 7ZPI chain A against the predicted model Q8R418: TM-score 0.92, RMSD 3.03 Å
- 7YYN chain A against the predicted model Q8R418: TM-score 0.92, RMSD 3.04 Å
- 3C4T chain A against the predicted model Q8R418: TM-score 0.72, RMSD 1.18 Å
- 3C4T chain A against the predicted model Q8R418: TM-score 0.72, RMSD 1.18 Å
- 3C4B chain A against the predicted model Q8R418: TM-score 0.71, RMSD 1.42 Å
- 3C4B chain A against the predicted model Q8R418: TM-score 0.71, RMSD 1.42 Å
- 7YZ4 chain A against the predicted model Q8R418: TM-score 0.55, RMSD 2.44 Å
- 7ZPK chain A against the predicted model Q8R418: TM-score 0.53, RMSD 3.23 Å
- 7ZPJ chain A against the predicted model Q8R418: TM-score 0.53, RMSD 3.28 Å
- 7YYM chain A against the predicted model Q8R418: TM-score 0.53, RMSD 2.87 Å
Elsewhere
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