UniProt Q8PY99
Glutamine synthetase (Q8PY99)
Glutamine synthetase (UniProt Q8PY99), EC 6.3.1.2: 5 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 105 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8PY99
- Protein
- Glutamine synthetase
- EC
- 6.3.1.2
- Experimental structures
- 5
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 105 · 6 records with a druggable one
Structures
6 records of Q8PY99 in the MolNFT archive: 5 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 8TFB | Cryo-EM structure of the Methanosarcina mazei apo glutamin synthetase structure: dodecameric form | electron microscopy | A, B, C, D, L, M, O, P, Q, V, X, Y | MG | 20 (best 0.83) |
| 8TFC | Cryo-EM structure of Methanosarcina mazie glutamine synthetase captured as partial oligomer | electron microscopy | A, B, D, L, O, P, Q, V | — | 20 (best 0.81) |
| 8TFK | Cryo-EM structure of the Methanosarcina mazei glutamine synthetase (GS) with Met-Sox-P and ADP | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | MG, P3S, ADP | 20 (best 0.82) |
| 8TGE | Crystal structure of the Methanosarcina mazei glutamine synthetase in complex with GlnK1 | x-ray diffraction | A, B, D, Y, M, P | — | 20 (best 0.81) |
| 8UFJ | Structure of M. mazei GS(R167L-A168G) apo form | x-ray diffraction | A, B, C | MG | 20 (best 0.81) |
| Q8PY99 | AlphaFold monomer V2.0 prediction for glutamine synthetase (Q8PY99) | predicted | A | — | 5 (best 0.57) |
Ligands
Experiment against prediction
- 8TFK chain A against the predicted model Q8PY99: TM-score 0.99, RMSD 0.63 Å
- 8TFC chain A against the predicted model Q8PY99: TM-score 0.98, RMSD 1.22 Å
- 8UFJ chain A against the predicted model Q8PY99: TM-score 0.98, RMSD 1.38 Å
- 8UFJ chain B against the predicted model Q8PY99: TM-score 0.98, RMSD 1.39 Å
- 8TGE chain A against the predicted model Q8PY99: TM-score 0.97, RMSD 1.39 Å
- 8TGE chain Y against the predicted model Q8PY99: TM-score 0.97, RMSD 1.40 Å
- 8TFB chain A against the predicted model Q8PY99: TM-score 0.97, RMSD 1.46 Å
Elsewhere
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