UniProt Q8PMP0
Methionine--tRNA ligase (Q8PMP0)
Methionine--tRNA ligase (UniProt Q8PMP0), EC 6.1.1.10: 8 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 15 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q8PMP0
- Protein
- Methionine--tRNA ligase
- EC
- 6.1.1.10
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 15 · 5 records with a druggable one
Structures
9 records of Q8PMP0 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6WQ6 | Xanthomonas citri Methionyl-tRNA synthetase in complex with methionine | x-ray diffraction | A | ZN, MET | 4 (best 0.63) |
| 6WQ6 | Xanthomonas citri methionyl-tRNA synthetase in complex with methionine | x-ray diffraction | A | ZN | — |
| 6WQI | Xanthomonas citri Methionyl-tRNA synthetase (apo) | x-ray diffraction | A, B | ZN | 4 (best 0.70) |
| 6WQI | Xanthomonas citri methionyl-tRNA synthetase (apo) | x-ray diffraction | A, B | ZN | — |
| 6WQS | Xanthomonas citri Methionyl-tRNA synthetase in complex with REP8839 | x-ray diffraction | A | ZN, U7S | 2 (best 0.69) |
| 6WQS | Xanthomonas citri methionyl-tRNA synthetase in complex with REP8839 | x-ray diffraction | A | ZN, U7S | — |
| 6WQT | Xanthomonas citri Methionyl-tRNA synthetase in complex with REP3123 | x-ray diffraction | A | ZN, U81 | 2 (best 0.68) |
| 6WQT | Xanthomonas citri methionyl-tRNA synthetase in complex with REP3123 | x-ray diffraction | A | ZN, U81 | — |
| Q8PMP0 | AlphaFold monomer V2.0 prediction for methionine--tRNA ligase (Q8PMP0) | predicted | A | — | 3 (best 0.73) |
Ligands
- ZN · Zinc ion · in 8 records
- U7S · 2-{[3-({[4-bromo-5-(1-fluoroethenyl)-3-methylthiophen-2-yl]methyl}amino)propyl]amino}quinolin-4(1H)-one · in 2 records
- U81 · 5-[(3-{[(4R)-6,8-dibromo-3,4-dihydro-2H-1-benzopyran-4-yl]amino}propyl)amino]thieno[3,2-b]pyridin-7(6H)-one · in 2 records
- MET · Methionine · in 1 record
Experiment against prediction
- 6WQ6 chain A against the predicted model Q8PMP0: TM-score 0.99, RMSD 0.94 Å
- 6WQ6 chain A against the predicted model Q8PMP0: TM-score 0.99, RMSD 0.94 Å
- 6WQT chain A against the predicted model Q8PMP0: TM-score 0.99, RMSD 1.01 Å
- 6WQT chain A against the predicted model Q8PMP0: TM-score 0.99, RMSD 1.01 Å
- 6WQI chain B against the predicted model Q8PMP0: TM-score 0.99, RMSD 1.02 Å
- 6WQI chain A against the predicted model Q8PMP0: TM-score 0.99, RMSD 1.02 Å
- 6WQI chain A against the predicted model Q8PMP0: TM-score 0.99, RMSD 1.02 Å
- 6WQS chain A against the predicted model Q8PMP0: TM-score 0.98, RMSD 1.10 Å
- 6WQS chain A against the predicted model Q8PMP0: TM-score 0.98, RMSD 1.10 Å
Elsewhere
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