UniProt Q8NHM5

Lysine-specific demethylase 2B (Q8NHM5)

Lysine-specific demethylase 2B (UniProt Q8NHM5), EC 1.14.11.27: 6 experimental structures and 1 predicted model on GenesisL1, 16 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: Q8NHM5
Protein: Lysine-specific demethylase 2B
EC: 1.14.11.27
Experimental structures: 6
Predicted models: 1
Pockets: 16 · 2 records with a druggable one

Structures

7 records of Q8NHM5 in the MolNFT archive: 6 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4O64	Zinc fingers of KDM2B	x-ray diffraction	A, B, C	—	—
4O64	Zinc fingers of KDM2B	x-ray diffraction	A, B, C	—	—
5JH5	Structural Basis for the Hierarchical Assembly of the Core of PRC1.1	x-ray diffraction	A	—	4 (best 0.68)
5JH5	Structural basis for the hierarchical assembly of the core of PRC1.1	x-ray diffraction	A	—	—
6BVA	Ubiquitin Variant (UbV.Fl10.1) bound to a human Skp1-Fbl10 fragment complex.	x-ray diffraction	E, F	—	3 (best 0.49)
6BVA	Ubiquitin variant (UBV.FL10.1) bound to a human SKP1-FBL10 fragment complex.	x-ray diffraction	E, F	—	—
Q8NHM5	AlphaFold monomer V2.0 prediction for lysine-specific demethylase 2B (Q8NHM5)	predicted	A	—	9 (best 0.79)

Experiment against prediction

5JH5 chain A against the predicted model Q8NHM5: TM-score 0.97, RMSD 1.31 Å
5JH5 chain A against the predicted model Q8NHM5: TM-score 0.97, RMSD 1.31 Å
4O64 chain A against the predicted model Q8NHM5: TM-score 0.93, RMSD 1.13 Å
4O64 chain A against the predicted model Q8NHM5: TM-score 0.93, RMSD 1.13 Å
4O64 chain B against the predicted model Q8NHM5: TM-score 0.91, RMSD 1.34 Å
4O64 chain B against the predicted model Q8NHM5: TM-score 0.91, RMSD 1.34 Å
6BVA chain E against the predicted model Q8NHM5: TM-score 0.82, RMSD 0.99 Å
6BVA chain E against the predicted model Q8NHM5: TM-score 0.82, RMSD 0.99 Å

Elsewhere

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