UniProt Q8NEZ4
Histone-lysine N-methyltransferase 2C (Q8NEZ4)
Histone-lysine N-methyltransferase 2C (UniProt Q8NEZ4), EC 2.1.1.43: 17 experimental structures on GenesisL1, 3 ligands bound, 19 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q8NEZ4
- Protein
- Histone-lysine N-methyltransferase 2C
- EC
- 2.1.1.43
- Experimental structures
- 17
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 19 · 2 records with a druggable one
Structures
17 records of Q8NEZ4 in the MolNFT archive: 17 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2YSM | Solution structure of the second and third PHD domain from Histone-lysine N-methyltransferase 2C… | solution nmr | A | ZN | 1 (best 0.38) |
| 2YSM | Solution structure of the second and third phd domain from histone- lysine N-methyltransferase 2C… | solution nmr | A | — | — |
| 2YUK | Solution structure of the HMG box of human Myeloid/lymphoid or mixed-lineage leukemia protein 3… | solution nmr | A | — | 1 (best 0.27) |
| 2YUK | Solution structure of the hmg box of human MYELOID/LYMPHOID or mixed- lineage leukemia protein 3… | solution nmr | A | — | — |
| 3UVL | Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL3 | x-ray diffraction | B | — | — |
| 3UVL | Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL3 | x-ray diffraction | B | — | — |
| 4ERY | X-ray structure of WDR5-MLL3 Win motif peptide binary complex | x-ray diffraction | D | — | — |
| 4ERY | X-ray structure of WDR5-MLL3 win motif peptide binary complex | x-ray diffraction | D | — | — |
| 5F59 | The crystal structure of MLL3 SET domain | x-ray diffraction | A | ZN | — |
| 5F59 | The crystal structure of MLL3 set domain | x-ray diffraction | A | — | — |
| 5F6K | Crystal structure of the MLL3-Ash2L-RbBP5 complex | x-ray diffraction | C, E | ZN | — |
| 5F6K | Crystal structure of the MLL3-ASH2L-RBBP5 complex | x-ray diffraction | C, E | — | — |
| 6KIW | Cryo-EM structure of human MLL3-ubNCP complex (4.0 angstrom) | electron microscopy | K | ZN | 5 (best 0.77) |
| 6KIW | Cryo-EM structure of human MLL3-ubncp complex (4.0 ångström) | electron microscopy | K | ZN | — |
| 6MLC | PHD6 domain of MLL3 in complex with histone H4 | x-ray diffraction | A, B, C, D | ZN, UNX | 7 (best 0.50) |
| 6MLC | PHD6 domain of MLL3 in complex with histone H4 | x-ray diffraction | A, B, C, D | ZN, UNX | — |
| 7W6L | The crystal structure of MLL3-RBBP5-ASH2L in complex with H3K4me0 peptide | x-ray diffraction | C, E | ZN, SAH | 5 (best 0.71) |
Ligands
Elsewhere
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