UniProt Q8NCM2

Potassium voltage-gated channel subfamily H member 5 (Q8NCM2)

Potassium voltage-gated channel subfamily H member 5 (UniProt Q8NCM2): 5 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 108 pockets. Binding sites, druggability and experiment against prediction…

UniProt: Q8NCM2
Protein: Potassium voltage-gated channel subfamily H member 5
Experimental structures: 5
Predicted models: 1
Ligands: 1
Pockets: 108 · 6 records with a druggable one

Structures

6 records of Q8NCM2 in the MolNFT archive: 5 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
7YID	Human KCNH5 closed state 1	electron microscopy	A, B, C, D	K	20 (best 0.73)
7YIE	Human KCNH5-closed state 2	electron microscopy	A, B, C, D	K	20 (best 0.76)
7YIF	Human KCNH5 pre-open state 1	electron microscopy	A, B, C, D	K	20 (best 0.86)
7YIH	Human KCNH5 open state	electron microscopy	A, B, C, D	K	20 (best 0.78)
7YIJ	Human KCNH5 pore dilation but the non-conducting state	electron microscopy	A, B, C, D	K	20 (best 0.77)
Q8NCM2	AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily H member 5 (Q8NCM2)	predicted	A	—	8 (best 0.68)

Ligands

K · Potassium ion · in 5 records

Experiment against prediction

7YIF chain A against the predicted model Q8NCM2: TM-score 0.96, RMSD 1.75 Å
7YIE chain A against the predicted model Q8NCM2: TM-score 0.95, RMSD 2.03 Å
7YID chain D against the predicted model Q8NCM2: TM-score 0.95, RMSD 2.06 Å
7YID chain A against the predicted model Q8NCM2: TM-score 0.95, RMSD 2.06 Å
7YID chain C against the predicted model Q8NCM2: TM-score 0.95, RMSD 2.06 Å
7YID chain B against the predicted model Q8NCM2: TM-score 0.95, RMSD 2.06 Å
7YIH chain A against the predicted model Q8NCM2: TM-score 0.92, RMSD 2.89 Å
7YIJ chain A against the predicted model Q8NCM2: TM-score 0.91, RMSD 3.07 Å

Elsewhere

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